Cytotoxic effect of nitric oxide on human hematological malignant cells

• Autorzy: Tsumori M. , Tanaka J. , Koshimura K. , Kawaguchi M. , Murakami Y. , Kato Y.
• Języki publikacji: EN

Abstrakty

EN

We investigated the cytotoxic effect of nitric oxide (NO) on primary culture of human hematological malignant cells. Sodium nitroprusside (SNP), an NO donor, had cytotoxic effects on the cells of some patients with malignant lymphoma (ML), acute myelocytic leukemia (AML) or chronic myelomonocytic leukemia (CMMoL), but not with multiple myeloma. Cultured cells from the ML patient remained sensitive to SNP after the cells became resistant to anti-cancer drugs. In contrast, the cells from the pa­tients with AML and CMMoL became resistant to SNP while anti-cancer drugs re­mained effective. In samples of the cells of the patients with ML and AML, the number of CD3 positive lymphoma cell was decreased by SNP and the number of CD33 nega­tive cells and normal B lymphocytes (CD19 positive cells) were increased. In the cells of the patient with ML, apoptosis was induced by SNP. SNP had no effect on lympho­cytes of healthy volunteers. These results suggest that SNP had an anti-tumor effect on human hematological malignant cells.

Słowa kluczowe

EN

lymphoma; chronic myelomonocytic leukemia; man; myeloma; leukemia; nitric oxide; acute myelocytic leukemia; malignant cell; cytotoxic effect; malignant lymphoma

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2002
• Tom: 49
• Numer: 1
• Opis fizyczny: p.139-144,fig.

Twórcy

autor

Tsumori M.

• Shimane Medical University, 89-1 Enya-cho, Izumo, 693-8501, Japan

autor

Tanaka J.

autor

Koshimura K.

autor

Kawaguchi M.

autor

Murakami Y.

autor

Kato Y.

Bibliografia

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