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2008 | 64 | 08 |

Tytuł artykułu

Rozmieszczenie i kinetyka zanikania zieleni malachitowej i zieleni leukomalachitowej w tkankach i narzadach karpia

Warianty tytułu

EN
Tissue distribution and persistence of malachite green and leucomalachite green in common carp

Języki publikacji

PL

Abstrakty

EN
Malachite green (MG) is a synthetic triphenylmethane dye that has been used worldwide as a fungicide and ectoparasicide in cultured fish eggs, fingerlings and adult fish since the 1930s. Due to its potential animal carcinogenicity, mutagenity, and teratogenicity, MG is not registered for veterinary use in many countries, including the European Union. The aim of this study was to investigate the tissue distribution and persistence of MG and its main metabolite, leucomalachite green (LMG), in carp after a therapeutic bath. On day 0, MG concentration in all tissues exceeded the initial concentration in therapeutic water (2 mg/l). Subsequently, the dye was rapidly and extensively metabolized to LMG, which was slowly eliminated from the tissues. Higher concentrations of MG and LMG were detected in the gills, liver and kidneys than in the spleen and muscles. The parent compound was more persistent in kidneys, liver and spleen (up to 112 days) than in the gills and muscles (up to 56 days). LMG concentrations declined more slowly in all tissues, being still detectable in kidneys and muscles 252 days after treatment.

Wydawca

-

Rocznik

Tom

64

Numer

08

Opis fizyczny

s.1055-1058,rys.,tab.,bibliogr.

Twórcy

autor
  • Panstwowy Instytut Weterynaryjny - Panstwowy Instytut Badawczy, Al.Partyzantow 57, 24-100 Pulawy
autor
autor

Bibliografia

  • 1.Alderman D. J., Clifton-Hadley R. S.: Malachite green: a pharmacokinetic study in rainbow trout, Oncorhynchus mykiss (Walbaum). J. Fish Dis. 1993, 16, 297-311.
  • 2.Allen J. L., Gofus J. E., Meinertz J. R.: Determination of malachite green residues in the eggs, fry, and adult muscle tissue of rainbow trout (Oncorhynchus mykiss). J.AOAC Int. 1994, 77, 553-557.
  • 3.Anon.: Commission Decision 2004/25/EC of 22 December 2003 amending Decision 2002/657/EC as regards the setting of minimum required performance limits (MRPL) for certain residues in food of animal origin. Off. J. Eur. Commun. 2004, L 6, 38-39.
  • 4.Anon.: Council Regulation 2377/90/EC of 26 June 1990 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin. Off. J. Eur. Comment. 1990, L 224, 1-8.
  • 5.Antychowicz J.: Choroby i zatrucia ryb. Wydawnictwo SGGW, Warszawa 1996.
  • 6.Bauer K., Dangschat H., Knoppler H. O., Neudegger J.: Aufnahme und Ausscheidung von Malachitgrün bei Regenbogenforellen. Arch. Lebensmittelhyg. 1988, 39, 85-108.
  • 7.Bergwerff A. A., Kuiper R. V., Scherpenisse P.: Persistance of residues of malachite green in juvenile eels (Anguilla anguilla). Aquaculture 2004, 233, 55-63.
  • 8.Culp S. J.: NTP technical report on the toxicity studies of malachite green chloride and leucomalachite green (CAS Nos. 569-64-2 and 129-73-7) administered in feed to F344/N rats and B6C3F1 mice. Toxic. Rep. Ser. 2004, 71, 1-10.
  • 9.Máchová J., Svobodová Z., Svobodnik J., Piaèka V., Vykusová B., Kocová A.: Persistence of malachite green in tissues of rainbow trout after a long-term therapeutic bath. Acta Vet. Brno 1996, 65, 151-159.
  • 10.Mitrowska K., Posyniak A.: Zieleñ malachitowa aspekty farmakologiczne, toksykologiczne i kontrola pozostałości. Medycyna Wet. 2005, 61, 742-745.
  • 11.Mitrowska K., Posyniak A., Żmudzki J.: Determination of malachite green and leucomalachite green in carp muscle by liquid chromatography with visible and fluorescence detection. J. Chromatogr. A 2005, 1089, 187-192.
  • 12.Plaks S. M., El Said K. R., Stehly G. R., Gingerich W. H., Allen J. L.: Uptake, tissue distribution, and metabolism of malachite green in channel catfih (Ictalurus punctatus). 1996 Can. J. Fish. Aquat. Sci. 53, 1417-1433.
  • 13.Plakas S. M., El Said K. E., Stehley G. R., Roybal J. E.: Optimization of a liquid chromatographic method for determination of malachite green and its metabolites in fish tissues. J. AOAC Int. 1995, 78, 1388-1394.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-ee940663-373e-461f-9609-ecbc4783c52a
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