Lead turnover and changes in the body status of chosen micro- and macroelements in rats exposed to lead and ethanol

• Autorzy: Moniuszko-Jakoniuk J , Jurczuk M. , Galazyn-Sidorczuk M. , Brzoska M.M.
• Języki publikacji: EN

Abstrakty

EN

The effect of continuous exposure to lead (Pb) and ethanol on Pb turnover and zinc (Zn), copper (Cu), iron (Fe), calcium (Ca) and magnesium (Mg) body status was studied in male Wistar rats. The animals received an aqueous solution of 10% (w/v) ethanol and/or 500 μg Pb/cm³ as the only drinking fluid for 12 weeks. Exposure to Pb as well as ethanol alone influenced the body status of Zn, Cu, Fe, Ca and Mg. Disturbances in their metabolism were reflected in decreased bioavailability, changes in serum and/or tissue concentrations and urinary excretion. The most serious disorders under Pb influence were observed in Fe metabolism, while ethanol alone disturbed mainly Fe, Cu and Zn body status. In the conditions of co-exposure to Pb and ethanol some changes were more or less evident and sometimes they had different direction than at separate intoxication. Moreover, simultaneous exposure to Pb and ethanol led to changes in the concentrations of Cu, Fe and Mg, which were not observed in the case of separate administration. The independent action of Pb and/or ethanol as well as the interactive effect of both substances involving the modifying influence of ethanol on Pb turnover could explain the changes in the metabolism of bioelements under combined exposure to Pb and ethanol. Our results seem to indicate that Pb-exposed human subjects abusing ethanol may be more vulnerable to the accumulation of Pb in body organs and metabolic disorders of some bioelements, which may in consequence enhance the risk of health injury.

Słowa kluczowe

EN

iron; environment pollutant; magnesium; interaction; bioelement; lead; rat; macroelement; calcium; ethanol; metabolism; microelement; toxicity; zinc; copper; heavy metal

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2003
• Tom: 12
• Numer: 3
• Opis fizyczny: p.335-344,fig.

Twórcy

autor

Moniuszko-Jakoniuk J

• Medical Academy, Mickiewicza 2c str., 15-222 Bialystok, Poland

autor

Jurczuk M.

autor

Galazyn-Sidorczuk M.

autor

Brzoska M.M.

Bibliografia

• 1. CARRINGTON C. D., BOLGER P. M., SCHEUPLEIN R. J. Risk analysis of dietary lead exposure. Food Addit. Contam. 13, 61, 1996.
• 2. MONIUSZKO-JAKONIUK J., BRZÓSKA M. M. Patomechanisms of salubrious effects of lead exposure. Pol. Jour. Environ. Stud. 6 (Suppl.), 38, 1997.
• 3. LIN J.L., TAN D. T., HSU K. H. , YU C. C. Environmental lead exposure and progressive renal insufficiency. Arch. Int. Med 161, 264, 2001.
• 4. GORDON J. N., TAYLOR A., BENNETT P. N. Lead poisoning: case studies. Brit. J. Clin. Pharmacol. 53, 451, 2002.
• 5. DALLY S., GIRRE C., HISPARD E., THOMAS G., FOURNIER L. High blood lead level in alcoholics: wine vs. beer. Drug Alcohol Depend. 23, 45, 1989.
• 6. MARANELLI G., APOSTOLI P., FERRARI P. Influence of smoking, alcohol, and dietary habits on blood Pb and Cd levels. Bull. Environ. Contam. Toxicol. 45, 804, 1990.
• 7. FLORA S. J. S., KUMAR D., SACHAN S. R. S., GUPTA S. D. Combined exposure to lead and ethanol on tissue concentration of essential metals and some biochemical indices in rat. Biol. Trace. Elem. Res. 28, 157, 1991.
• 8. CEZARD C., DEMARQUILLY C., BONIFACE M., HAGUENOERN J. M. Influence of the degree of exposure to lead on relations between alcohol consumption and the biological indices of lead exposure: epidemiological study in a lead acid battery factory. Brit. J. Ind. Med. 49, 645, 1992.
• 9. WÓJCIK A., BRZESKI Z. Some chosen heavy metals in the state of acute alcohol intoxication and alcohol disease. Pol. Jour. Environ. Stud. 6 (Suppl.), 199, 1997.
• 10. JINDAL V., GILL K. D. Ethanol potentiates leadinduced inhibition of rat brain antioxidant defense systems. Pharmacol. Toxicol. 85, 16, 1999.
• 11. GUPTA V, GILL K. D. Influence of ethanol on lead distribution and biochemical changes in rats exposed to lead. Alcohol 20, 9, 2000.
• 12. MAHAFFEY K. R., CAPAR S. G., GLADEN B. C., FOWLER B. A. Concurrent exposure to lead, cadmium, and arsenic. Effect on toxicity and tissue metal concentrations in the rat. J. Lab. Clin. Med. 98, 463, 1981.
• 13. BOGDEN J. D., GERTNER S. B., CHRISTAKOS S., KEMP F. W., YANG Z., KATZ S. R., CHU C. Dietary calcium modifies concentrations of lead and other metals and renal calbidin in rats. J. Nutr. 122, 1351, 1992.
• 14. GONZALEZ-REIMERS E., MARTINEZ-RIERA A., SANTOLARIA-FERNANDEZ F., MAS-PASCUAL A., RODRIGUEZ-MORENO F., GALINDO-MARTIN L., MOLINA-PEREZ M., BARROS-LOPEZ N. Relative and combined effects of ethanol and protein deficiency on zinc, iron, copper, and manganese contents in different organs and urinary and faecal excretion. Alcohol 16, 7, 1998.
• 15. PASTERNAK K. Tissue concentrations of magnesium in rats receiving various dosages of ethanol. Magnesium Res. 12, 167, 1999.
• 16. FLORIAŃCZYK B. Zinc level in selected tissues of ethanol and morphine intoxicated mice. Med. Sci. Monit. 6, 680, 2000.
• 17. WHITFIELD J. B., ZHU G., HEATH A. C., POWELL L. W., MARTIN N. G. Effects of alcohol consumption on indices of iron stores and alcohol intake markers. Alcohol. Clin. Exp. Res. 25, 1037, 2001.
• 18. BRZÓSKA M. M., MONIUSZKO-JAKONIUK J., JURCZUK M., GAŁAŻYN-SIDORCZUK M., ROGALSKA J. Effect of shortterm ethanol administration on cadmium retention and bioelements metabolism in rats continuously exposed to cadmium. Alcohol Alcohol. 35, 439, 2000.
• 19. BRZÓSKA M. M , MONIUSZKO-JAKONIUK J., JURCZUK M., GAŁAŻYN-SIDORCZUK M. Cadmium turnover and changes of zinc and copper body status of rats continuously exposed to cadmium and ethanol. Alcohol Alcohol. 37, 213, 2002.
• 20. PERAZA M. A., AYALA-FIERRO F., BARBER D. S., CASAREZ E., RAEL L.T. Effects of micronutrients on metal toxicity. Environ. Health Perspect. 106 (Suppl. 1), 203, 1998.
• 21. PIZENT A., JURASOVIE J., TELISMAN S. Blood pressure in relation to dietary calcium intake, alcohol consumption, blood lead, and blood cadmium in female nonsmokers. J. Trace Elem. Med. Biol. 15, 123, 2001.
• 22. SCHIOELER P. Alcoholrelated problems for primary health care workers. Development of National Training Seminar. WHO Euro, Copenhagen. 1991.
• 23. MEYER C., RUMPF H. J., HAPKE U., DILLING H., JOHN U. Prevalence of alcohol consumption, abuse and dependence in a country with higher per capita consumption: findings from the German TACOS study. Transitions in Alcohol Consumption and Smoking. Soc. Psychiatry Psychiatr. Epidemiol. 35, 539, 2000.
• 24. GILES A. R. Guidelines for the use of animals in biomedical research. Thromb. Haemost. 58, 1078, 1987.
• 25. RAŹNIEWSKA G., TRZCINKA-OCHOCKA M. The use of flameless AAS for determining lead and cadmium in blood and cadmium, copper, nickel and chromium in urine. Med. Pracy 46, 347, 1995. (in Polish)
• 26. MONIUSZKO-JAKONIUK J., JURCZUK M., GAŁAŻYN-SIDORCZUK M., BRZÓSKA M. M., ŚWIĄTEK E. The changes in chosen parameters of iron metabolism in rats after exposure to cadmium and ethanol. Pol. Jour. Environ. Stud. 8 (Suppl. 2), 158, 1999.
• 27. BRZÓSKA M. M., MONIUSZKO-JAKONIUK J., PIŁAT-MARCINKIEWICZ B., SAWICKI B. Liver and kidney function and histology in rats exposed to cadmium and ethanol. Alcohol Alcohol. – in press.
• 28. LEE S. S., LEE B. K., LEE G. S., STEWART W. F., SIMON D., KELSEY K., TODD A. C., SCHWARTZ B. S. Association of lead biomarkers and deltaaminolevulinic acid dehydratase and vitamin D receptor genotypes with hematopoietic outcomes in Korean lead workers. Scand. J. Work Environ. Health 27, 402, 2001.
• 29. TODD A. C., GINDE N. R., HO C. K., LUO J. C., TOLMAN J., TSAI J. L., WU T. N., LIOU S. H. A pilot evaluation of tibia lead concentrations in Taiwan. Am. J. Ind. Med. 40, 127, 2001.
• 30. WIŚNIEWSKA-KNYPL J. M., WROŃSKA-NOFER T. Biological marker of oxidative stress induced by ethanol and iron overload in rats. Int. J. Occup. Med. Environ. Health 7, 355, 1994.
• 31. FLORA S. J. S., TANDON S. K. Effect of combined exposure to lead and ethanol on some biochemical indices in the rat. Biochem. Pharmacol. 36, 537, 1987.
• 32. TANDON S. K., TEWARI P. C. Effect of coexposure to ethanol and cadmium in rats. Bull. Environ. Contam. Toxicol. 39, 633, 1987.
• 33. MASSIE H. R., AIELLO V. R. Lead accumulation in the bones of aging male mice. Gerontology 38, 13, 1992.
• 34. McNEILL F. E., STOKES L., BRITO J. A., CHETTLE D. R., KAYE W.E. 109Cd K x ray fluorescence measurements of tibial lead content in young adults exposed to lead in early childhood. Occup. Environ. Med. 57, 465, 2000.
• 35. PAL R., NATH R., GILL K. D. Influence of ethanol on cadmium accumulation and its impact on lipid peroxidation and membrane bound functional enzymes (Na+,K+ATPase and acetylcholinesterase) in various regions of adult rat brain. Neurochem. Invest. 23, 451, 1993.
• 36. KULIKOWSKA E., MONIUSZKO-JAKONIUK J., JABŁOŃSKA E., KAŁUŻYŃSKI A. The influence of ethanol on tissue distribution and the toxic effects of lead on rats. Pol. Jour. Environ. Stud. 4, 51, 1995.
• 37. FRIDAY K. E., HOWARD G. A. Ethanol inhibits human bone cell proliferation and function in vitro. Metabolism 40, 562, 1991.
• 38. AITIO A., JARVISALO J., RIHHIMAKI V., HERNBERG S. Biological monitoring. In Occupational Medicine, Zenz C ed.; Year Book Medical Publishers Inc.: Chicago, London, Boca Raton, pp 178198, 1988.
• 39. PREEDY V. R., BALDWIN D. R., KEATING J.W., SALISBURY J. S. Bone collagen, mineral and trace element composition, histomorphometry and urinary hydroxyproline excretion in chronicallytreated alcoholfed rats. Alcohol Alcohol. 26, 39, 1991.
• 40. SHARMA G., SANDHIR R., NATH R., GILL K. Effect of ethanol on cadmium uptake and metabolism of zinc and copper in rats exposed to cadmium. J. Nutr. 121, 87, 1991.
• 41. COUDRAY C., TRESSOL J. C., FEILLET-COUDRAY C., BELLANGER J., PEPIN D., MAZUR A. Longterm consumption of red wine does not modify intestinal absorption or status of zinc and copper in rats. J. Nutr. 130, 1309, 2000.