Human papillomavirus [HPV] and Epstein-Barr virus [EBV] cervical infections in women with normal and abnormal cytology

• Autorzy: Szkaradkiewicz A , Wal M. , Kuch A. , Pieta P.
• Języki publikacji: EN

Abstrakty

EN

In 48 adult women, subdivided into group 1 with no cervical intraepithelial neoplasia (CIN-negative) and group 2 (CIN-positive), endocervical scrapes were tested for the presence EBV DNA and HPV DNA using PCR-ELISA. In addition, attempts were made to detect HPV 16 and HPV 18 using other PCR amplification techniques. In parallel, in biopsies of uterine cervix obtained from group 2 patients, presence of EBER was documented by RNA in situ hybridization (ISH). Sera of all patients were tested for anti-EBV antibodies. In group 1, presence of EBV DNA was noted in the material obtained from 8 women (30.8%), while HPV DNA was detected in 2 women (7.7%). In group 2, EBV DNA was present in the material obtained from 11 patients (50%), including 7 (31.8%) with HPV DNA also identified. In 5 women (22.7%) of group 2 only HPV DNA was detected. The identifical HPV DNA in all cases belonged to HPV 16 type. Both in group 1 and in group 2, all patients were found to carry serum IgG-anti-VCA and IgG-anti-EBNA antibodies. The results allow to conclude that, co-infection with EBV and HPV 16 may be of cervical significance in etiopathogenesis of uterine cervical cancer.

Słowa kluczowe

EN

cervical infection; virus; carcinogenesis; cervical neoplasia; woman; abnormal cytology; human papillomavirus; normal cytology; Epstein-Barr virus

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2004
• Tom: 53
• Numer: 2
• Opis fizyczny: p.95-99,fig.,ref.

Twórcy

autor

Szkaradkiewicz A

• Poznan University of Medical Sciences, Wieniawskiego 3, 61-712 Poznan, Poland

autor

Wal M.

autor

Kuch A.

autor

Pieta P.

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