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2008 | 52 | 1 |

Tytuł artykułu

Evaluation of the efficacy of iron polymaltose complex in the prevention of anaemia in piglets

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of this study was to evaluate the efficacy of oral application of iron polymaltose complex (IPC) in the prevention of iron deficiency in piglets. The piglets in group I (n = 15) were treated with iron dextran (200 mg of Fe³⁺, i.m.) at the age of 3 d. In group II (n = 19), the piglets were given 100 mg of Fe³⁺ as IPC orally at the age of 3 and 11 d. The piglets in group III (n = 19) received oral application of 100 mg of Fe²⁺ ferrous fumarate at the age of 3 and 11 d. The piglets in group IV (n = 12) served as an iron deficient control group. The haemoglobin concentration and iron concentration in blood plasma in IPC treated group were comparable to the ferrous fumarate group. It is concluded that the IPC showed a comparable efficacy of IPC in the anaemia prevention as ferrous fumarate.

Wydawca

-

Rocznik

Tom

52

Numer

1

Opis fizyczny

p.119-123,fig.,ref.

Twórcy

autor
  • University of Veterinary and Pharmaceutical Science, 612 42 Brno, Czech Republic
autor
autor

Bibliografia

  • 1. Arnon S., Shiff Y., Litmanovitz I., Regev R. H., Bauer S., Shaikin-Kestenbaum R., Bental Y., Dolfin T.: The efficacy and safety of early supplementation of iron polymaltose complex in preterm infants. Am J Perinatal 2007, 24, 95-100.
  • 2. Arvas A., Gür E.: Are ferric compounds useful in treatment of iron deficiency anemia? Turk J Pediatr 2000, 42, 352-353.
  • 3. Borbolla J.R., Cicero R.C., Dibildox M., Gutiérrez R.G.: Polymaltózový železitý komplex vs síran železitý pří léčení anémie z nedostatku železa u kojenců. Vox Pediatrie 2003, 3, 37-40.
  • 4. Dietzfelbinger H.: Bioavailability of bi- and trivalent oral iron preparations. Investigations of iron absorption by post-absorption serum iron concentrations curves Ärzneimittelforschung 1987, 37, 107-112.
  • 5. Egeli A. K., Framstad T., Norbert H.: Clinical biochemistry, hematology and body weight in piglets. Acta Vet Scand 1998, 39, 381-393.
  • 6. Erichsen K., Ulvik R.J., Grimstad T., Berstad A., Berge R.K., Hausken T.: Effects of ferrous sulphate and non- polymaltose complex on markers of oxidative tissue damage in patients with inflammatory bowel disease. Aliment Pharmacol Ther 2005, 22, 831-838.
  • 7. Geisser P., Muller A.: Iron pharmacokinetics after administration of ferric-hydroxide-polymaltose complex in rats. Arzneim-Forsch 1984, 34, 1560-1569.
  • 8. Geisser P., Müller A.: Pharmacokinetics of iron salts and ferric hydroxide-carbohydrate complexes. Arzneim-Forsch 1987, 37, 100-104.
  • 9. Geisser P.: In vitro studies on interactions of iron salts and complexes with food-stuffs and medicaments. Arzneimittelforschung 1990, 40, 754-760.
  • 10. Hallberg L., Ryttinger L., Solvell L.: Side effects of oral iron therapy. A double blind study of different iron compounds in tablet form. Acta Med Scand 1966, 459, 3-10.
  • 11. Jacobs P., Wood L., Bird A. R.: Erythrocytes: better tolerance of iron-polymaltose complex compared with ferrous sulphate in the treatment of anaemia. Hematology 2005, 5, 77-83.
  • 12. Jacobs P.: Equivalent bioavailability of iron from ferrous salts and a ferric polymaltose complex. Clinical and experimental studies. Arzneimittelforschung 1987, 37, 113-116.
  • 13. Kaltwasser J. P., Werner E., Niechzial M.: Bioavailability and therapeutic efficacy of bivalent and trivalent iron preparations. Arzneim-Forsch 1987, 37, 122-129.
  • 14. Kickier T.S., Borowitz M.J., Thompson R.E., Charintranont N., Law R.: RET-Y a measure of reticulocyte size: a sensitive indicator of iron deficiency anemia. Clin Lab Haematol 2004, 26, 423- 427.
  • 15. Kotrbáček V.: Effects of different formulae for oral and parenteral administration of iron on somatic growth and selected haematological indexes in piglets. Czech J Anim Sci 2001, 46, 49-54.
  • 16. Malhotra S., Garg S.K., Khullar G.K., Malhotra A.S., Kondal A., Rana H., Sidhu S.: Kinetics of two different iron formulations and their effect on diurnal variation of serum iron levels. Meth Find Exp Clin Pharmacol 2004, 25, 417-420.
  • 17. Mehta B. C.: Iron hydroxide polymaltose-cause of persistent iron deficiency anemia at delivery. Indian J Med Sci 2001, 55, 616-620.
  • 18. Nielsen P., Gabbe E.E., Fischer R., Heinrich H.C.: Bioavailability of iron from oral ferric polymaltose in humans. Arzneimittelforschung 1994, 44, 743-748.
  • 19. Reddy P.S.N., Adsul B.B., Gandewar K., Korde K.M., Desai A.: Evaluation of efficacy and safety of iron polymaltose complex and folic acid (mumfer) vs iron formulation (ferrous fumarate) in female patients with anaemia. J Indian Med Assoc 2001, 99, 154-155.
  • 20. Saha L., Pandhi P., Gopalan S., Malhotra S., Saha P.K: Comparison of efficacy, tolerability, and cost of iron polymaltose complex with ferrous sulphate in the treatment of iron deficiency anemia in pregnant women. Med Gen Med 2007, 9, 1.
  • 21. Sas G., Nemesanszky E., Brauer H., Scheffer K.: On the therapeutic effects of trivalent and divalent iron in iron deficiency anaemia. Arzneim Forsch Drug Res 1984, 34, 1575-1579.
  • 22. Svoboda M., Bouda J., Drábek J., Doubek J.: Effect of per os iron lactate supplement on development of haematological profile of piglets in the early postnatal period. Acta Vet Brno 2004, 73, 431-436.
  • 23. Svoboda M., Drábek J.: Effect of oral administration of Fe-fumarate on erytrocyte profile and growth rate of suckling piglets. Acta Vet Brno 2002, 72, 431-436.
  • 24. Tuomainen T.P., Nyyssonen K., Porkkala-Sarataho E., Salonen R., Baumgartner J.A., Geisser P., Salonen J.T.: Oral supplementation with ferrous sulfate but not with non- ionic iron polymaltose complex increases the susceptibility of plasma lipoproteins to oxidation. Nutr Res 1999, 19, 1121-1132.
  • 25. Venn J.A.J., McCance R.A., Widdowson E.M.: Iron metabolism in piglet anemia J Comp Pathol 1947, 57, 314-325.
  • 26. Yu I. T., Lin J., Wu J.F., Yen H.T., Lee S.L., Yang T.S.: Revaluation of the necessity of iron injection to newborn piglets. Asian-Australian J Anim Sci 2002, 15, 79-83.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-e8e38f4f-5b17-41a8-8452-c9d5562475c2
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