Metoda oznaczania aktywnosci mutagennej substancji smolowych zawartych w pylach powietrza atmosferycznego

• Autorzy: Krogulski A. , Borkowska M.
• Języki publikacji: PL

Abstrakty

PL

W pracy przedstawiono metodą oznaczania aktywności mutagennej ekstraktu cykloheksanowego pyłów powietrza atmosferycznego. Użyto zmodyfikowanego testu somatycznej mutacji i re-kombinacji u muszki owocowej (SMART)

EN

For assessing of the environmental contamination with potentially carcinogenic mutagens the possibility of the measurement of the mutagenic activity of the substances absorbed on dust suspended in air would be important. These substances include at least several hundreds of organic compounds. Only a small part of them have been studied in detail, and, on the other hand, it is known that at least a score of them are carcinogenic. Additionally, the prescence of some of them can change significantly the action of other ones. Because of that, the effects of a mixture of these substances should be studied as a whole. The fact that the discussed contaminants are present in the air and can be transported over great distances causes that they are dangerous to man both directly (when inhaled) and trough contamination of water, soil and food. Paraleli use in the described method of two cross-bred strains of fruit flies made possible separate assessment of the activity of mutagens and promutangens requiring activation in presence of cytochrome P 450. The use of the eukaryotic organism in which mutations are observed in many cells in one individual (about 2500) enables reliable data to be obtained about the degree of human health risk.

Słowa kluczowe

PL

zagrozenia zdrowia; substancje smolowe; powietrze atmosferyczne; czynniki rakotworcze; pyly; zanieczyszczenia powietrza; aktywnosc mutagenna; zanieczyszczenia srodowiska

EN

health hazard; atmospheric air; carcinogenic factor; dust; air contaminant; mutagenic activity; environment contaminant

• Wydawca: -
• Czasopismo: Roczniki Państwowego Zakładu Higieny
• Rocznik: 1996
• Tom: 47
• Numer: 2
• Opis fizyczny: s.175-180,wykr.,bibliogr.

Twórcy

autor

Krogulski A.

• Panstwowy Zaklad Higieny, 00-791 Warszawa, ul.Chocimska 24

autor

Borkowska M.