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2010 | 19 | 2 |

Tytuł artykułu

Can silver nanoparticles affect the mineral content, structure and mechanical properties of chicken embryo bones?

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Biomedical application of silver nanoparticles has recently gained much attention. In this study, we investigated whether hydrocolloids of silver nanoparticles (nano-Ag) are deposited in chicken bones during embryogenesis and to what extent they can affect biochemical characteristics, mineral content, structure, and mechanical properties of bones. Hydrocolloids (0.3 ml), containing 50 ppm of nano-Ag, were injected in ovo prior to incubation of eggs. After 20 days of incubation, blood and thigh bones were isolated and analysed. Nano-Ag was deposited in embryo thigh bones, but did not affect the structure or mechanical properties of the bone. There was no effect of nano-Ag on the selected biochemical indices, but there was a tendency towards increasing mineral content, indicating that nanoparticles may influence bone mineralization. Considering that nano-Ag is absorbed by the embryo skeleton without affecting bone properties, these particles might be a good candidate for carriers of micronutrients or drugs into bones.

Wydawca

-

Rocznik

Tom

19

Numer

2

Opis fizyczny

p.286-291,fig.,ref.

Twórcy

autor
  • Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland
autor
autor
autor
autor
autor

Bibliografia

  • Bhattacharya R., Mukherjee P., 2008. Biological properties of „naked” metal nanoparticles. Advan. Drug Delivery Rev. 60, 1289-1306
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  • Currey D.J., 2004b. Incompatible mechanical properties in compact bone. Theor. Biol. 231, 569-580
  • Dziedzic-Gocławska A., 1995. Bone tissue (in Polish). In: Histology. PZWL, pp. 244-305
  • Foye O.T., Uni Z., Ferket P.R., 2006. Effect of in ovo feeding egg white protein, beta-hydroxy-betamethylbutyrate, and carbohydrates on glycogen status and neonatal growth of turkeys. Poultry Sci. 85, 1185-1192
  • Gralak M.A., Piastowska A.W., Leontowicz H., Leontowicz M., Antczak A., Kulasek G., Szara T., Narojek T., 2004. Effect of dietary protein level and sources on bone mineralization and structure in rats. Biofactors 22, 25-28
  • Johnston P., Comar C., 1955. Distribution of calcium from the albumen, yolk and shell to the developing chick embryo. Amer. J. Physiol. 183, 365-370
  • Kim Y.S., Kim J.S., Cho H.S., Rha D.S., Kim J.M., Park J.D., Choi B.S., Lim R., Chang H.K., Chung Y.H., Kwon I.H., Jeong J., Han B.S., Yu I.J., 2008. Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats. Inhal. Toxicol. 20, 575-583
  • Leeson T., Leeson C., 1963. The chorioallantoic of the chick. Light and electron microscopic observations at various times of incubation. J. Anat. 97, 585-559
  • Libby P., Aikawa M., 2002. Vitamin C, collagen, and cracks in the plaque. Circulation 105, 1396-1398
  • Nagy A.J., Mestl G., Herein D., Weinberg G., Kitzelmann E., Schlögl R., 1999. The correlation of subsurface oxygen diffusion with variations of silver morphology in the silver–oxygen system. J. Catal. 182, 417-429
  • Puls R., 1995. Mineral Levels in Animal Health. Diagnostic Data. Serpa International, Clearbrook Rai M., Yadav A., Gade A., 2009. Silver nanoparticles as a new generation of antimicrobials. Biotech. Adv. 27, 76-83
  • Salata O.V., 2004. Application of nanoparticles in bio0logy and medicine. J. Nanobiotech. 2, 1-6
  • Sawosz E., Grodzik M., Zielińska M., Niemiec T., Olszańska B., Chwalibog A., 2009. Nanoparticles of silver do not affect growth, development and DNA oxidative damage in chicken embryos. Arch. Geflϋgelk. 73, 208-213
  • Szulc P., Beck T.J., Marchand F., Delmas P.D., 2005. Low skeletal muscle mass is associated with poor structural parameters of bone and impaired balance in elderly men – The MINOS study. J. Bone Miner. Res. 20, 721-729
  • Williams D., 2002. Medical technology: How small we can go? Med. Device Tech. 4, 7-9

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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