Differences in stimulation of CD45plus cells from mouse spleen population enriched in dendritic cells depending on the virulence of herpes simplex virus type 1 strains

• Autorzy: Rechnio M , Siennicka J. , Gut W. , Litwinska B.
• Języki publikacji: EN

Abstrakty

EN

The interaction of CD28 with one of the B7 molecules (CD80 and CD86) on professional antigen-presenting cells (APC) is generally considered to be the most important co-stimulatory signal for T cell activation. Several lines of evidence suggest that dendritic cells (DC), the most potent antigen presenting cells known, play a role in the immunological control of herpes simplex virus (HSV) infections. The fact that CD86 is strongly up-regulated together with other co-stimulatory molecules during DC maturation suggests that it plays an important role in induction of immune response. To determine the effect of virulence on up-regulation of CD86, we stimulated population of spleen cells enriched in dendritic cells by HSV-1 strains characterised by different pathogenicity. We analysed cells, which express CD45 molecule. HSV-1 ts, earlier described as less virulent for mice, stimulated an increased expression of co-stimulatory molecule CD86 than wild strain did.

Słowa kluczowe

EN

mouse; mice; immune stimulation; dendritic cell; pathogen; virulence; herpes simplex virus type 1; spleen cell; viral pathogen; Herpesviridae; antigen-specific response

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2004
• Tom: 53
• Numer: 3
• Opis fizyczny: p.151-154,fig.,ref.

Twórcy

autor

Rechnio M

• National Institute of Hygiene, Warsaw, Poland

autor

Siennicka J.

autor

Gut W.

autor

Litwinska B.

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