Prospects for p53-based cancer therapy

• Autorzy: Stoklosa T. , Golab J.
• Języki publikacji: EN

Abstrakty

EN

The p53 tumor suppressor plays the role of a cellular hub which gathers stress signals such as damage to DNA or hypoxia and translates them into a complex response. p53 exerts its action mainly as a potent transcription factor. The two major outcomes of p53 activity are highlighted: cell cycle arrest and apoptosis. During malignant transformation p53 or p53-pathway related molecules are disabled extremely often. Mutations in p53 gene are present in every second human tumor. A mutant form of p53 may not only negate the wild type p53 function but may play additional role in tumor progression. Therefore p53 represents a relatively unique and specific target for anticancer drug design. Current approaches include several different molecules able to restore p53 wild-type conformation and activity. Such small molecule drugs hold great promise in treating human tumors with dysfunction of p53 pathway in the near future.

Słowa kluczowe

EN

tumour suppressor gene; therapy; small molecule inhibitor; stress response; cancer; p53 gene; p53 molecule

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2005
• Tom: 52
• Numer: 2
• Opis fizyczny: p.321-328,fig.,ref.

Twórcy

autor

Stoklosa T.

• Medical University of Warsaw, Warsaw, Poland

autor

Golab J.

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