Cellular level of 8-oxo-2'-deoxyguanosine in DNA does not correlate with urinary excretion of the modified base nucleoside

• Autorzy: Foksinski M. , Gackowski D. , Rozalski R. , Olinski R.
• Języki publikacji: EN

Abstrakty

EN

We assessed a relationship between the level of 8-oxodG in leukocyte DNA measured with the high performance liquid chromatography with electrochemical detection (HPLC/EC) technique and urinary excretion of the modified nucleoside/base ana­lysed with a recently developed methodology involving HPLC prepurification fol­lowed by gas chromatography with isotope dilution mass spectrometric detection. No correlation was found between these markers of oxidative DNA damage commonly used in epidemiological studies. Several possible explanations of this finding are dis­cussed.

Słowa kluczowe

EN

nucleoside; gas chromatography; 8-oxo-2'-deoxyguanosine; DNA damage; oxidative DNA damage; 8-oxoguanine; DNA; high performance liquid chromatography; urinary excretion

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2003
• Tom: 50
• Numer: 2
• Opis fizyczny: p.549-553,fig.

Twórcy

autor

Foksinski M.

• The Ludwik Rydygier Medical University in Bydgoszcz, Bydgoszcz, Poland

autor

Gackowski D.

autor

Rozalski R.

autor

Olinski R.

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