Influence of liver`s oxide-reductive homeostasis disorder for AKBR values in rabbit`s arterial blood

• Autorzy: Wardas M. , Aleksiewicz R. , Pawlowska-Goral K. , Adamiak Z. , Kostrzewski M. , Sierocinski M.
• Języki publikacji: EN

Abstrakty

EN

The keton bodies are created generally in a liver, but this organ has no enzymatic system able to metabolize them. A dependence exists between the molar acetoacetate concentration and the molar ß-hydroxybutyrate concentration, and it can be an indicator of quantitive relations between NAD and NADH. Metabolic reserve can be estimated on the basis of the molar concentration of keton bodies in the arterial blood - of the AKBR value. Tests were carried out on specially prepared rabbit arterial blood samples. Because there is no way to measure NAD to NADH cocentrations in the liver directly a relationship between acetoacetate and ß-hydroxybutarate serves to estimate of the oxydo-reductive status of this key organ. That is why AKBR values seem to be extremely important. Vitamin E is known for it's cytoprotective influence of hepatic cells damage. In the presented paper we've challenged this hypothesis by analysing of correlation between AKBR values in examined rabbit group.

Słowa kluczowe

EN

tetrachloralmethane; metabolism; homeostasis; ketogenesis; antioxidant; free radical; liver; rabbit; arterial blood

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2007
• Tom: 10
• Numer: 1
• Opis fizyczny: p.29-33,fig.,ref.

Twórcy

autor

Wardas M.

• Silesian Medical Academy, Jagiellonska 4, 41-200 Sosnowiec, Poland

autor

Aleksiewicz R.

autor

Pawlowska-Goral K.

autor

Adamiak Z.

autor

Kostrzewski M.

autor

Sierocinski M.

Bibliografia

• Bojes HK, Thurman RG (1996) Potent peroxisome prolifer- ators inhibit beta-oxidation in the isolated perfused rat liver. Toxicol Appl Pharmacol 140: 322-327.
• Brennan RJ, Schiestl RH (1998) Chloroform and CC14 in­duce intrachromosomal recombination and oxidative free radical in Saccharomyces cerevisiae. Mutat Res 397: 271-278.
• Brent JA, Rumack BH (1993) Role of free radicals in toxic hepatic injury. J Toxicol Clin Toxicol 31: 139-171.
• Caban A, Wiaderkiewicz R, Kaminski M, Oczkowicz G, Ziaja J (2000)Arterial ketone index in assessing liver function and its detoxicative capability after ischemia-re- perfusion injury. Acta Biochim Pol 47: 1137-1146.
• Galelli ME, Castor JA (1998) Effect of trichloromethyl and trichloromethyl peroxyl free radicals on protein sulphyd- ryl content studies in model and in enzymatic carbon tet­rachloride activation system. Res Commun Mol Pathol Pharmacol 100: 227-238.
• Gondko R (1995) Cyclical radicals changes in the body. Postępy Biochem 41: 243-247.
• Ikadea K, Toda M, Tanaka K, Takumara S, Kojo S (1998) Increase of lipid hydroperoxides in liver mitochondria and inhibition of cytochrome oxidase by carbon tetrach­loride intoxication in rats. Free Radie Res 28: 403-410.
• Kono H, Fuji H, Matsuda M, Yamamoto M, Matsumoto Y (2001) Gadolinium chloride prevents mortality in hepatectomized rats given endotoxin. J Surg Res 96: 204-210.
• Lardinois OM, Mestdagh M, Rouxhet PG (1996) Reversible inhibition and reversible inactivation of catalysis in pres­ence of hydrogen peroxidel. Biochim Biophys Acta 1295: 222-238.
• Smuckler EA (1976) Structural and functional changes in acute liver injury. Environ Health Prospect 15: 13-25.
• Takahasi M, Ueda K, Tabata R, Iwata S, Ozawa K, Uno S, Kinoshita M (1997) Arterial keton body ratio as a prog-nostic indicator in acute heart failure. J Lab Clin Med 129: 72-80.
• Williamson, DH, Mellanby J, Krebs HA (1962) Enzymic de­termination of D-(-)-hydroxybutyric acid and acetoacetic acid in blood. Biochem J 82: 90-96.
• Williamson DH, Lund P, Krebs HA (1967) The redox state of free nicotinamide deanine dinucleotide in the cytop­lasm and mitochondrials of rat liver. Biochem J 103: 514-527.