Structure-based design of the antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione TX-1123 as a protein tyrosine kinase inhibitor having low mitochondrial toxicity

• Autorzy: Hori H , Nagasawa H. , Uto Y.
• Języki publikacji: EN

Słowa kluczowe

EN

structure; therapeutic agent; cell differentiation; tyrphostin; treatment; mitochondrial toxicity; signal transduction; apoptosis; cancer; proliferative disorder; cell division; protein tyrosine kinase

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2003
• Tom: 08
• Numer: 2A
• Opis fizyczny: p.528-530

Twórcy

autor

Hori H

• The University of Tokushima, Tokushima 770-8506, Japan

autor

Nagasawa H.

autor

Uto Y.

Bibliografia

• 1. Hori, H., Nagasawa, H. , Ishibashi, M., Uto, Y., Hirata, A., Saijo, K., Ohkura, K., Kirk, K.L. and Uehara, Y. TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-l,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity. Bioorg. Med. Chem. 10 (2002) 3257-3265.
• 2. Levitzki, A. and Gazit, A. Tyrosine kinase inhibition: an approach to drug development. Science 267 (1995) 1782-1788.
• 3. Supko, J.G., Malspeis, L., Sausville, E.A., Burger, A., Alley, M., and Grever, M.R. Identification of the antitumor activity and preclinical evaluation of the benzylidenemalononitrile derivative NSC 242557. Proc. Am. Assoc. Cancer Res. 35 (1994) 424-425.
• 4. Ohkura, K. and Hori, H. Modification of cell response to insulin by membrane-acting agents in rat white adipocytes: analysis of structural features by computational simulation. Bioorg. Med. Chem. 9 (2001) 3023- 3033.
• 5. Burger, A.M., Kaur, G., Alley, M.C., Supko, J.G., Malspeis, L., Grever, M.R. and Sausville, E.A. Tyrphostin AG17, [(3,5-Di-tert-butyl-4- hydroxybenzylidene)- malononitrile], inhibits cell growth by disrupting mitochondria. Cancer Res. 55 (1995) 2794-2799.
• 6. Palumbo, G.A., Yarom, N., Gazit, A., Sandalon, Z., Baniyash, M., Kleinberger-Doron, N., Levitzki, A., Ben-Yehuda, D. The tryphostin AG17 induces apoptosis and inhibition of cdk2 activity in a lymphoma cell line that overexpresses bcl-2. Cancer Res. 57 (1997) 2434-2439.
• 7. Sausville, E.A. Correspondence re: G. Palumbo et al., the tyrphostin AG17 induces apoptosis and inhibition of cdk2 activity in a lymphoma cell line that overexpresses bcl-2. Cancer Res., 57: 2434-2439, 1997. Cancer Res. 57 (1997) 5610.
• 8. Muraoka, S. and Terada, H. 3,5-di-tert-butyl-4-hydroxybenzylidene-malononitrile; A new powerful uncoupler of respiratory-chain phosphorylation. Biochim. Biophys. Acta 275 (1972) 271-275.
• 9. Shimamura, M., Nagasawa, H., Ashino, H., Yamamoto, Y., Hazato, T., Uto, Y., Hori, H. and Inayama, S. A novel hypoxia-dependent 2-nitroimidazole KIN-841 inhibits tumour-specific angiogenesis by blocking production of angiogenic factors. Br. J. Cancer 88 (2003) 307-313.
• 10. Nagasawa, H., Yamashita, M., Mikamo, N., Shimamura, M., Oka, S., Uto, Y. and Hori, H. Design, synthesis and biological activities of antiangiogenic hypoxic cytotoxin, triazine-A-oxide derivatives. Comp. Biochem. Physiol. Part A, Mol. Integr. Physiol. 132 (2002) 33-40.
• 11. Kasai, S., Nagasawa, H., Yamashita, M., Masui, M., Kuwasaka, H., Oshodani, T., Uto, Y., Inomata, T., Oka, S., Inayama, S. and Hori, H. New antimetastatic hypoxic cell radiosensitizers: design, synthesis, and biological activities of 2-nitroimidazole-acetamide, TX-1877 and its analogues. Bioorg. Med. Chem. 9 (2001) 453-564.