Effect of some lysosomotropic substances on erythrocyte membrane

• Autorzy: Kleszczynska H. , Luczynski J. , Witek S. , Przestalski S.
• Języki publikacji: EN

Abstrakty

EN

The effect of N,N-dimethylaminoethyl esters of fatty acids (DM n) on pig red blood cell hemolysis and erythrocyte membrane fluidity has been investigated. In the hemolytic experiments the hemolytic activity of the compounds studied was determined, and was found to increase with alkyl chain length and followed the sequence: DM-15 > DM-13 > DM-11 > DMDA > DM-9. The fluorimetric studies were done using the fluorescent probe TMA-DPH, which allowed us to calculate polarization coefficient P and hence determine relative changes in membrane fluidity induced by the lysosomotropic substances. The compounds of highest hemolytic activity, which have fifteen- and thirteen-carbon-atom alkyl chain (DM-15 and DM-13), significantly affect the erythrocyte membrane fluidity.

Słowa kluczowe

EN

pig; erythrocyte membrane; erythrocyte; fluidity; N,N-dimethylaminoethyl ester; fatty acid; hemolysis

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 1997
• Tom: 06
• Numer: 6
• Opis fizyczny: p.21-24,fig.,ref.

Twórcy

autor

Kleszczynska H.

• Agricultural University, Norwida 25, 50-375 Wroclaw, Poland

autor

Luczynski J.

autor

Witek S.

autor

Przestalski S.