Effect of pre- and postnatal exposure to zinc on [3H]glucose uptake in the brain and peripheral tissues of adult rats

• Autorzy: Konecki J , Bielaczyc G. , Nowak P. , Szkilnik R. , Szczerbak G. , Swoboda M. , Kwiecinski A. , Kostrzewa R.M. , Brus R.
• Języki publikacji: EN

Abstrakty

EN

To determine the susceptibility of developing brain and other tissues to accumulate zinc, rats were exposed to zinc at different periods of ontogeny. For the prenatal group, pregnant Wistar rats received 50 ppm of zinc (ZnSO₄ · 7H₂O) in drinking for the entire duration of pregnancy. On the day of delivery zinc was removed from the drinking water. Another group, dams, received 50 ppm of zinc in drinking water only during the suckling period (from delivery until the 21st day of postnatal life). Their offspring were weaned on the 21st day, at which time zinc was removed from the drinking water. The control group drank tap water only. At 3 weeks after birth, the level of zinc was estimated in the brain, liver, mandibular bone and kidney of offspring from all groups. At 8 weeks after birth 6-[³H]D-glucose (500 µCi/kg) was administered IP to male offspring, 15 minutes before sacrifice. By liquid scintillation spectroscopy, ³H-activity (expressed as disintegrations per minute [DPM]) was determined in discrete parts of the brain and some peripheral tissues, and expressed as DPM/100 mg of tissue, wet weight. It was found that the highest amount of zinc was accumulated in the brain and liver of rat offspring that were exposed to zinc postnatally. [³H]-activity was at lower levels, in comparison, in nearly all other parts of the brain of rats exposed to zinc postnatally. In offspring receiving zinc prenatally, zinc levels were at similar or lower amounts in the brain and peripheral tissues, vs. the group with postnatal exposure. From this study in rats we conclude that zinc accumulates to the highest extent in brain, following a later ontogenetic (postnatal) exposure period, and by this, there is also greater disturbance of metabolic processes associated with glucose utilization.

Słowa kluczowe

EN

6-[3H]D-glucose; glucose; adult rat; brain; development; zinc; exposure; rat; peripheral tissue

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2006
• Tom: 15
• Numer: 2
• Opis fizyczny: p.291-295,ref.

Twórcy

autor

Konecki J

• Medical University of Silesia, 41-808 Zabrze, Poland

autor

Bielaczyc G.

autor

Nowak P.

autor

Szkilnik R.

autor

Szczerbak G.

autor

Swoboda M.

autor

Kwiecinski A.

autor

Kostrzewa R.M.

autor

Brus R.

Bibliografia

• 1. GOYER R.A. Toxic effect of metals. in Casarett and Doull’s Toxicology – The Basic Science of Poisoning (Amdur M.O., Doull J., Klassen C.D., eds), Pergamon Press, pp. 623-680, 1991.
• 2. DAVIES N.T. Studies on absorption of zinc by rat intestine. Br. J. Nutr. 43, 189, 1980.
• 3. CLEGG M.S., KEEN C.C., HURLEY L.S. Biochemical pathologies of zinc deficiency. in Zinc in Human Biology (Mills C.F., ed.), Springer-Verlag, New York, pp. 129-145, 1989.
• 4. PRASAD A.S. Clinical manifestation of zinc deficiency. Ann. Rev. Nutr. 5, 341, 1985.
• 5. FURST A. Bioassay of metals for carcinogenesis: whole animals. Enviroy. Health Perpect. 40, 83, 1984.
• 6. LEONARD A., GEBER G.B., LEONARD F. Mutagenicity, carcinogenicity and teratogenicity of zinc. Mutal. Res. 168, 343, 1986.
• 7. ROGERS J.M. An introduction to developmental and reproductive toxicology of metals. in Toxicology of Metals (Chang L.W., ed), Lewis Publishers, Boco Raton pp. 975-1001, 1996.
• 8. HAZELHOFF-ROELFZEMA W.H., ROELFSEN A.M., LEENE W., COPIUS PEEREBOOM-STEGEMAN J.H.J. Effect of cadmium exposure during pregnancy on cadmium and zinc concentration in neonatal liver and consequences for the offsprings. Arch. Toxicol. 63, 38, 1989.
• 9. MUTCH P.B., HURLEY L.S. Effect of zinc deficiency during lactation on postnatal growth and development of rats. J. Nutr. 104, E26, 1974.
• 10. ROMEO I.A., ABBOTT N.J., BRADBURY M.W.B. The blood-brain barrier in normal CNS and in metal-induced neurotoxicity. in Toxicology of Metals (Chang L.W., ed.), Lewis Publishers, Boca Raton, pp. 561-585, 1996
• 11. BRUS R., SZKILNIK R., NOWAK P., SAWCZUK K., KONECKI J., SŁOTA P., SHANI J. Central exposure of pregnant rats to cadmium and diazepam change the reactivity of the central dopaminergic, serotoninergic and muscarinic receptors, as well as of glucose uptake in their offspring. Pharmacol. Rev. Comm. 10, 93, 1998.
• 12. WHITESIDE P. Atomic Absorption. Pye Unicam Ltd., Cambridge, UK, 1976.
• 13. HARPER’S BIOCHEMISTRY. (Murray R.K., Granner D.K., Mayes P.A., Rodwell V.W., eds), Prentice-Hall International Inc. 1994.
• 14. CHANCE W.T., CAO L., FISHER J.E. Brain 3-methoxytyramine varies inversely with blood glucose in decapitated rats. Pharmacol. Biochem. Behav. 32, 553, 1989.
• 15. MONTEFUSCO O., ASSINI M.C., MISSALE C. Insulinmediated effects of glucose on dopamine metabolism. Acta Diabetol. Lat. 20, 71, 1983.
• 16. BITTAR M.L., KOULU M., RAPPORT S., LINNOILA M. Diabetes-induced alteration in brain monoamine metabolism in rats. J. Pharm. Exp. Ther. 236, 432, 1986.
• 17. SALLER S.F. Dopaminergic activity is reduced in diabetic rats. Neurosci. Lett. 49, 301, 1984.
• 18. SAUTER A., GOLDSTEIN M., ENGEL J., UETA K. Effect of insulin on central catecholamines. Brain Res. 260, 330, 1983.
• 19. WIESEL F.A., WIK G., SJOGREN I., BIOMQUIST G., GREEN T. Altered relationship between metabolic rates of glucose in brain regions of schizophrenic patients. Acta Psychiat. Scand. 76, 642, 1987.
• 20. BRUS R., SZKILNIK R., KOSTRZEWA R.M., JĘDRUSIAK I., KONECKI J., GŁOWACKA M., SHANI J. Modulation of glucose uptake in rat brain after administration of quinpirole and SKF-38393, two central dopamine-receptor agonist. Pharmacol. Rev. Comm. 7, 87, 1995.
• 21. SZKILNIK R., OŚWIĘCIMSKA J., BRUS R., KONECKI J., KARASIŃSKA A., SHANI J. Modulation of glucose uptake in rat’s brain, heart, liver and kidneys, after administration of quinpirole and 7-OH-DPAT, two central dopamine-D3 receptor agonists. Pharmacol. Rev. Comm. 10, 321, 1999.
• 22. BRUS R., SZKILNIK R., NOWAK P., KONECKI J., GŁOWACKA M., KASPERSKA A., OŚWIĘCIMSKA J., SAWCZUK K., SHANI J. Prenatal exposure of rats to lead, induce changes in the reactivity of the central dopaminergic, serotoninergic and muscarinic receptors, but not in glucose uptake in their offspring. Pharmacol. Rev. Comm. 9, 299, 1997.
• 23. BRUS R., SZKILNIK R., KONECKI J., STĘPIEŃ M., MAŁECKI S., KUBALLA G., MENGEL K., SHANI J. Prenatal exposure of rats to manganese: changes in reactivity of their central dopaminergic, serotoninergic and muscarinic receptors, but not glucose uptake in their adult offsprings. Pharmacol. Rev. Comm. 12, 9, 2002.
• 24. SZKILNIK R., NOWAK P., BRUS R., KONECKI J., KARASIŃSKA A., KOSTECZKO A., WINIARSKA H., SHANI J. Effect of cadmium and dizocilpine (MK-801), administered to pregnant rats, on reactivity of central dopamine receptors, glucose uptake and cadmium levels in their offsprings. Pharmacol. Rev. Comm. 11, 183, 2001.
• 25. BRUS R., SZKILNIK R., KONECKI J., GŁOWACKA M., POPIELUCH I., SAWCZUK K., NYTKO Ł., SHANI J. Short-term changes in glucose uptake in rat brain and some peripheral tissues after consumption of aluminium, as a function of ontogenic development. Pharmacol. Rev. Comm. 9, 53, 1997.
• 26. KISZKA W., SZKILNIK R., BRUS R., NOWAK P., KONECKI J., DURCZOK A., MENGEL K., SHANI J. Prenatal exposure of rats to mercury induce changes in central dopaminergic activity and in glucose uptake by their offspring. Pharmacol. Rev. Comm. 12, 77, 2002.
• 27. ILONZ R., KAIDANOVICH O., GURWITZ D., ELDARFINKELMAN H. Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: Insight into the insulin-mimetic action of zinc. Biochem. Biophys. Res. Commun. 295, 102, 2002.
• 28. TANG X., SHAY N.V. Zinc has an insulin-like effect on glucose transport mediated by phosphoinosital-3-kinase and Akt in 323-L1 fibrablast and adipocytes. J. Nutr. 131, 1414, 2001.
• 29. BLUMENTHAL S., LEWAND D., SOCHANIK A., KREZOSKI S., PETERING D.H. Inhibition of Na+-glucose cotransport in kidney cortical cells by cadmium and copp.er: Protection by zinc. Toxicol. App.l. Pharmacol. 129, 177, 1994.
• 30. BRÄTTER P., NEGRETTI de BRÄTTER V.E., RECKNAGEL S., BRUNETTO R. Maternal selenium status influences the concentration and binding pattern of zinc in human milk. J. Trace Elements Med. Biol. 11, 203, 1997.
• 31. DAVIES N.T. Studies on the absorption of zinc by rat intestine. Br. J. Nutr. 43, 189, 1980.
• 32. DASTON G.P., LEHMAN-McKEEMAN L.D. Constitutive and induced metallothionein expression in development. in Toxicology of Metals (Chang L.W. ed), Lewis Publishers, Boca Raton, pp. 1139-1151, 1996.
• 33. GOYER R.A., CHERIAN M.G. Role of metallothionein in human placenta and rats exposed to cadmium. in Cadmium in the Human Environment: Toxicity and Carcinogenicity (Nordberg G.E., Herber R.F.M., Alesio L., eds), International Agency for Research of Cancer. Lyon, pp. 239-247, 1992.
• 34. CLARK B.J. The role of dopamine in periphery. in The dopaminergic system (Flückinger E., Müller E.E., Thorner M.O., eds), Springer, Sandoz. Berlin, pp. 27-39, 1985.