Increased activity of phospholipase C in aortas of spontaneously hypertensive rats correlates with decreased sphingomyelin: total phospholipid ratio

• Autorzy: Gryckiewicz E. , Dettlaff A. , Pawelczyk T.
• Języki publikacji: EN

Abstrakty

EN

The activity of phospholipase C (PLC) in the aortas of spontaneously hypertensive rats (SHR) was higher than in the aortas of age-matched normotensive Wistar-Kyoto rats (WKY). This was associated with the higher level of inositol 1,4,5-trisphosphate and diacylglycerol in aortas of SHR compared to the level of these compounds found in aortas of WKY. Observed changes in PLC activity correlates with changes in phospholipid composition of SHR aortas. The sphingomyelin (SM) to total phospholipid ratio decreased significantly in aortas of SHR compared to WKY. Since, SM was proposed to be the major PLC δ inhibitor in vivo (Arch. Biochem. Biophys. 297 (1992) 328-333) it might be possible that observed higher activity of PLC in aortas of SHR results from decreased content of this phospholipid.

Słowa kluczowe

EN

phospholipase C; biological membrane; erythrocyte; concentration; hypertension; lipid composition; total phospholipid; aorta; cholesterol; rat; blood pressure; phospholipid

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 1998
• Tom: 03
• Numer: 1
• Opis fizyczny: p.3-11,fig.

Twórcy

autor

Gryckiewicz E.

• Medical University of Gdansk, 80-211 Gdansk, Poland

autor

Dettlaff A.

autor

Pawelczyk T.

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