Inhibition of mammalian topoisomerase I by 1-nitro-9-aminoacridines. Dependence on thiol activation

• Autorzy: Ciesielska E. , Pastwa E. , Szmigiero L.
• Języki publikacji: EN

Abstrakty

EN

The cytotoxic activity, susceptibility to thiol activation and ability of eight 1-nitroacridine derivatives to stabilize the topoisomerase I-DNA cleavable complex, were compared. Among the acridines tested three compounds exhibited high ability to stabilize the cleavable complex. This ability was correlated with susceptibility to thiol activation as well as with cytotoxic activity. Our results suggest that 1-nitroacridine-DNA adducts interfering with topoisomerase I action may contribute to the lethal effects of some 1-nitroacridine derivatives.

Słowa kluczowe

EN

mammal; inhibition; thiol; topoisomerase I; 1-nitroacridine; nitracrine

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1997
• Tom: 44
• Numer: 4
• Opis fizyczny: p.775-780,fig.

Twórcy

autor

Ciesielska E.

• Medical University in Lodz, Lindleya 6, 90-131 Lodz, Poland

autor

Pastwa E.

autor

Szmigiero L.

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