EN
Assesments were made of the effect of lead and methylbromfenvinphos (IPO-63) on rat organisms after single and mixed intoxication. The analyses were based on acetylcholine esterase activity in blood and methylbromfenvinphos residues in liver. It was found that intoxication with lead acetate before methylbromfenvinphos increased AChE inhibition in blood, this effect being different depending on the type of intoxication and the period after the intoxication. It was also found that earlier applications of lead acetate resulted in the changes of methylbromfenvinphos biotransformation and differentiated accumulation of this insecticide in rat liver in particular periods of the experiment. The results depended to a large extent on the type of intoxication and the dose of lead acetate.