Interaction of the rat C-terminal fragment [Tyr 0]CGRP [28-37] with noradrenaline and acetylcholine in isolated uterine artery of the pig

• Autorzy: Dynarowicz I. , Jaroszewski J.J. , Markiewicz W.
• Języki publikacji: EN

Abstrakty

EN

In the present paper the influence of the rat C-terminal fragment [Tyr°]CGRP(28-37) (Ct-CGRP) was compared with the influences of noradrenaline (NA) and acetylcholine (ACh), respectively on isolated pig uterine artery (UA). It was shown that Ct-CGRP (10 -8 mol/1) caused contraction of UA, similar to NA (10-7 mol/1) action. ACh addition before Ct-CGRP treatment inhibited the action of this peptide. ACh administration after Ct-CGRP pretreatment negated the action of this peptide, whereas Ct-CGRP given before and after NA treatment caused additive contractile reactions of UA. Moreover, it was also shown that susceptibility of UA reaction on Ct-CGRP was higher in the postovulatory phase than in other phases of the oestrous cycle. But the effect of Ct-CGRP addition in NA pretreatment vessels as well as the influence of NA added after Ct-CGRP pretreatment were more marked in the luteal phase than in pre- and postovulatory phases of the cycle. Furthermore it was showed that CGRP (10 -9 mol/1) caused very strong dilatation of UA, equal to the reaction observed after ACh (10-8 mol/1) treatment. We concluded that Ct-CGRP in contrast to the whole molecule of calcitonin gene-related peptide (CGRP) caused vasocontractile activity in the isolated pig uterine artery. This effect was synergistic with NA action and was inhibited by ACh.

Słowa kluczowe

EN

pig; acetylcholine; interaction; noradrenaline; blood flow; uterine artery; reproductive organ; rat

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 1999
• Tom: 02
• Numer: 2
• Opis fizyczny: p.71-75,fig.

Twórcy

autor

Dynarowicz I.

• University of Agriculture and Technology, Oczapowskiego 13, 10-957 Olsztyn, Poland

autor

Jaroszewski J.J.

autor

Markiewicz W.