Korelacja stezen wybranych cytokin w wydzielinie pochwowo-szyjkowej u ciezarnych kobiet z roznymi mikroskopowymi obrazami tej wydzieliny

• Autorzy: Wasiela M. , Krzeminski Z. , Kalinka J. , Brzezinska-Blaszczyk E.

Warianty tytułu

EN

Correlation between levels of selected cytokines in cervico-vaginal fluid of women with abnormal vaginal bacterial flora

• Języki publikacji: PL

Abstrakty

PL

Celem pracy było ustalenie, w jakim stopniu u kobiet z bakteryjną waginozą wzrasta w środowisku pochwy stężenie czterech cytokin prozapalnych - IL-1α, IL-1ß, IL-6 oraz IL-8 - oraz czy istnieje jakiś wzajemny związek między wzrostem tych stężeń. Uzyskane wyniki wskazują na to, iż w bakteryjnej waginozie w środowisku pochwy wzrasta stężenie cytokin prozapalnych, najbardziej IL-1ß, IL-1α i IL-8, oraz że wzrost ten jest w pewnych przypadkach ze sobą skorelowany.

EN

The aim of this study was to evaluate the rise of the levels of proinflammatory cytokines -IL-1α, IL-1ß, IL-6 and IL-8 in vagina of women with bacterial vaginosis (BV) and if there is any relationship between this levels. One hundred and twenty females between 22nd and 36th week of pregnancy were enrolled in the study. According to the bacterial flora of cervico-vaginal fluid evaluated by Gram stain, all women were divided into three groups. Group I (53 females; 44.2%) - normal bacterial flora, group II (35 females; 29.2%) - intermediate flora, and group with ВV (32 females; 26.6%). The level of IL-1 b in women withBV was over twelve times higher than in women from I group (131.35 and 10.6 pg/mL respectively). The next was the level of IL-1α - about seven times higher (128.45 vs 19.1 pg/mL) and the levels of IL-6 and IL-8, which were 1.7 times higher (16.2 vs 9.7 pg/mL and 656.7 ví 375.3 pg/mL respectively). Except for IL-6 these differences of levels were statistically significant (p<0.05). The levels of IL-1β in group of women with BV correlated strongly with levels of IL-1α (r=0.72; p<0.0001) and weakly with levels of IL-6 (r=0.31; p=0.017). The correlation coefficient between levels of IL-6 and IL-8 rose gradually in II and BV group and reached levels r=0.575; p=0.0014 and r=0.67; p=0.0009 respectively. Our findings show that in vagina of women with BV the levels of proinflammatory cytokines rise, and that the rise of levels is in certain cases correlated.

Słowa kluczowe

PL

kobiety ciezarne; choroby czlowieka; choroby bakteryjne; waginoza; wydzielina pochwowo-szyjkowa; cytokiny; stezenie cytokin

• Wydawca: -
• Czasopismo: Medycyna Doświadczalna i Mikrobiologia
• Rocznik: 2005
• Tom: 57
• Numer: 3
• Opis fizyczny: s.327-333,rys.,tab.,bibliogr.

Twórcy

autor

Wasiela M.

• Uniwersytet Medyczny w Lodzi, ul.Pomorska 251, 92-213 Lodz

autor

Krzeminski Z.

autor

Kalinka J.

autor

Brzezinska-Blaszczyk E.

Bibliografia

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