The normal growth of the thoracic aorta in human foetuses

• Autorzy: Szpinda M
• Języki publikacji: EN

Abstrakty

EN

The present study was performed on 128 spontaneously aborted human foetuses aged 15–34 weeks in order to establish normal values for thoracic aorta dimensions at various gestational ages. Using anatomical dissection, digital-image analysis (the Leica QWin Pro 16 system) and statistical analysis (ANOVA, regression analysis) the growth of the length, the original and terminal external diameters and the volume of the thoracic aorta during gestation was examined. No significant gender differences were found (p > 0.05). The growth curves were generated of the best fit for the plot for each morphometric feature against gestational age. Both the length and external diameters of the thoracic aorta increased in proportion to the advance in foetal age. The length ranged from 12.49 ± 1.85 mm to 48.82 ± 6.31 mm according to the linear function y = –19.654 + 2.0512 x ± 3.5168. The original external diameter ranged from 1.25 ± 0.28 mm to 5.65 ± 0.48 mm according to the linear fashion y = –2.3834 + 0.2367 x ± 0.3850. The terminal external diameter ranged from 1.15 ± 0.26 mm to 5.18 ± 0.45 mm, in agreement with the linear model y = –2.1438 + 0.2156 x ± 0.3555 (r = 0.96, p < 0.001 for each feature). The volume of the thoracic aorta ranged from 15.75 ± 8.06 mm³ to 1158.01 ± 301.85 mm³ according to the quadratic function y = 1376.2 – 154.42 x + 4.419 x² ± 125.6 (R² = 0.90). The growth curves generated from my data may be useful as a reference for foetal echocardiographers, who must distinguish abnormal from normal foetal development.

Słowa kluczowe

EN

normal growth; regression analysis; man; external diameter; anatomy; human fetus; fetus; echocardiography; thoracic aorta

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2007
• Tom: 66
• Numer: 2
• Opis fizyczny: p.131-137,fig.,ref.

Twórcy

autor

Szpinda M

• The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Karlowicza 24, 85-092 Bydgoszcz, Poland

Bibliografia

• 1. Alvarez L, Aranega A, Saucedo R, Contreras JA, Lopez F, Aranega A (1990) Morphometric data concerning the great arterial trunks and their branches. Int J Cardiol, 29: 127–139.
• 2. Angelini A, Allan LD, Anderson RH, Crawford DC, Chita SK, Ho SY (1988) Measurements of the dimensions of the aortic and pulmonary pathways in the human fetus: a correlative echocardiographic and morphometric study. Br Heart J, 60: 221–226.
• 3. Firpo C, Hoffman J, Silverman NH (2001) Evaluation of fetal heart dimensions from 12 weeks to term. Am J Cardiol, 87: 594–600.
• 4. Hornberger LK, Weintraub RG, Pesonen E, Murilo-Olivas A, Simpson IA, Sahn C, Hagen-Ansert S, Sahn DJ (1992) Echocardiographic study of the morphology and growth of the aortic arch in the human fetus. Observations related to the prenatal diagnosis of coarctation. Circulation, 86: 741–747.
• 5. Hyett J, Moscoso G, Nicolaides K (1995) Morphometric analysis of the great vessels in early fetal life. Hum Reprod, 10: 3045–3048.
• 6. Iffy L, Jakobovits A, Westlake W, Wingate MB, Caterini H, Kanofsky P, Menduke H (1975) Early intrauterine development: I. The rate of growth of Caucasian embryos and fetuses between the 6th and 20th weeks of gestation. Pediatrics, 56: 173–186.
• 7. van Meurs-van Woezik H, Krediet P (1982) Measurements of the descending aorta in infants and children: comparison with other aortic dimensions. J Anat, 135: 273–279.
• 8. Nidorf SM, Picard MH, Triulzi MO, Thomas JD, Newell J, King ME, Weyman AE (1992) New perspectives in the assessment of cardiac chamber dimensions during development and adulthood. J Am Coll Cardiol, 19: 983–988.
• 9. Poutanen T, Tikanoja T, Sairanen H, Jokinen E (2003) Normal aortic dimensions and flow in 168 children and young adults. Clin Physiol Funct Imag, 23: 224–229.
• 10. Roman MJ, Devereux RB, Kramer-Fox R, O’Loughlin J (1989) Two-dimensional echocardiographic aortic root dimensions in normal children and adults. Am J Cardiol, 64: 507–512.
• 11. Rosenberg HS, Klima T, Henderson SR, McNamara DG (1971) Maturation of the aortic isthmus. Cardiovasc Res Cent Bull, 10: 47–56.
• 12. Rudolph AM, Heymann MA, Spitznas U (1972) Hemodynamic considerations in the development of narrowing of the aorta. Am J Cardiol, 30: 514–525.
• 13. Simpson J (2004) Echocardiographic evaluation of cardiac function in the fetus. Prenat Diagn, 24: 1081–1091.
• 14. Sinha SN, Kardatzke ML, Coles RB, Muster AJ, Wessel HU, Paul MH (1969) Coarctation of the aorta in infancy. Circulation, 40: 385–398.
• 15. Shinebourne EA, Elseed AM (1974) Relation between fetal flow patterns, coarctation of the aorta, and pulmonary blood flow. Br Heart J, 36: 492–498.
• 16. Szpinda M, Flisiński P, Elminowska-Wenda G, Flisiński M, Krakowiak-Sarnowska E (2005) The variability and morphometry of the brachiocephalic trunk in human foetuses. Folia Morphol, 64: 309–314.
• 17. Szpinda M, Brazis P, Elminowska-Wenda G, Wiśniewski M (2006) Morphometric study of the aortic and great pulmonary arterial pathways in human fetuses. Ann Anat, 188: 25–31.
• 18. Szpinda M, Szwesta A, Szpinda E (2007) Morphometric study of the ductus arteriosus during human development. Ann Anat, 189: 47–52.
• 19. Szpinda M (2007) Morphometric study of the ascending aorta in human fetuses. Ann Anat, doi: 10.1016/j.aanat. 2007.01.007 (in press, available online at www.sciencedirect.com).
• 20. Ursell PC, Byrne JM, Fears TR, Strobino BA, Gersony WM (1991) Growth of the great vessels in the normal human fetus and in the fetus with cardiac defects. Circulation, 84: 2028–2033.
• 21. Veille JC, Sivakoff M (1989) Two-dimensional and M-mode assessment of aortic growth in the normal and growth-retarded (IUGR) human fetuses. Pediatr Cardiol, 10: 61–63.