The role of nitric oxide in paraquat-induced oxidative stress in rat striatum

• Autorzy: Djukic M. , Jovanovic M.C. , Ninkovic M. , Vasiljevic I. , Jovanovic M.
• Języki publikacji: EN

Abstrakty

EN

The role of nitric oxide (NO) in paraquat (PQ)-induced neurotoxicity is still not fully understood. In this study we used NG-nitro-L-arginine methyl ester (L-NAME), a non-selective nitric oxide synthase (NOS) inhibitor, in order to examine the effects of NO, reactive oxygen species (ROS) generation and lipid peroxidation (LPO) development during PQ-mediated neurotoxicity. Oxidative stress development in the striatum of Wistar rats intrastriatally (i.s.) poisoned with PQ (and in some cases pre-treated with L-NAME) was investigated by measuring superoxide anion (O2 •ˉ), malondialdehyde (MDA) and nitrate (NO3ˉ), 30 min, 24 hours and 7 days after treatment. L-NAME pretreatment provided the possibility to distinguish the role of ROS from reactive nitrogen species (RNS) in oxidative stress development induced by PQ. Our results confi rm the involvement of NO in PQ-mediated neurotoxicity and reduced LPO by L-NAME pretreatment implying that the latter has a protective role.

Słowa kluczowe

EN

Wistar rat; brain; nitric oxide; paraquat; oxidative stress; pesticide; herbicide; neurotoxicity; exposure; rat

• Wydawca: -
• Czasopismo: Annals of Agricultural and Environmental Medicine
• Rocznik: 2007
• Tom: 14
• Numer: 2
• Opis fizyczny: p.247-252,fig.,ref.

Twórcy

autor

Djukic M.

• Belgrade University, Vojvode Stepe 450, 11221 Belgrade, Serbia

autor

Jovanovic M.C.

autor

Ninkovic M.

autor

Vasiljevic I.

autor

Jovanovic M.

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