Unexpected domain composition of MACC1 links MET signaling and apoptosis

• Autorzy: Kokoszynska K. , Krynski J. , Rychlewski L. , Wyrwicz L.S.
• Języki publikacji: EN

Abstrakty

EN

Colorectal cancer, one of the most challenging malignancies, still has a limited number of recognized prognostic and predictive markers indicating appropriate treatment. MACC1 (metastasis-associated in colon cancer-1), a novel regulator of tumor growth and metastasis has recently been identified as an important prognostic factor of metastatic disease in colorectal cancer. The mechanism of MACC1 activity remains undetermined. Here we apply a combination of fold recognition and homology modeling algorithms to draft MACC1 function. The applied methods revealed that the MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Previously a similar domain architecture (ZU5-DD) was observed in other proteins, involved mainly in signal transduction and apoptosis regulation. Based on the specific aspects of the closest homologues' biology functional hypotheses on MACC1 are proposed. A broad range of bioinformatic analyzes indicates that MACC1, besides its involvement in signal transduction from the MET receptor, links MET signaling and apoptosis.

Słowa kluczowe

PL

cancer; colorectal cancer; protein structure modelling; bioinformatics; apoptosis; tumour growth; metastasis; metastatic disease; prognostic factor; mesenchymal-epithelial transition factor; cellular signalling

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2009
• Tom: 56
• Numer: 2
• Opis fizyczny: p.317-323,fig.,ref.

Twórcy

autor

Kokoszynska K.

• Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, W.Roentgena 5, 02-781 Warsaw, Poland

autor

Krynski J.

autor

Rychlewski L.

autor

Wyrwicz L.S.

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