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2007 | 63 | 02 |

Tytuł artykułu

Regulacja immunologiczna w zarazeniach helmintami: ochrona przed alergia

Warianty tytułu

EN
Immune regulation during chronic nematode infections: protection from allergy

Języki publikacji

PL

Abstrakty

EN
There has been a worldwide increase in the prevalence of allergy. Parasite infections may have a varied influence on the outcome of allergic reactions. Of particular interest is the possibility that helminth infections may lessen the intensity of allergy symptoms. This may occur due to the immune regulatory network evoked by helminthes decreasing allergy through the action of regulatory T lymphocytes and cytokines such as IL-10 and TGF-β. The authors of the article discuss the latest research results in this field as well as laboratory studies describing the phenomena. The article also describes multiple mechanisms which may be utilized by helminths to mediate the suppression of allergy, and which involve regulatory lymphocytes and cytokines, helminthic molecules and polyclonal IgE.

Wydawca

-

Rocznik

Tom

63

Numer

02

Opis fizyczny

s.147-150,bibliogr.

Twórcy

autor
  • Uniwersytet Warszawski, ul.Miecznikowa 1, 02-096 Warszawa

Bibliografia

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  • 2. Akdis M., Verhagen J., Taylor A., Karamloo F., Karagiannidis C., Crameri R., Thunberg S., Deniz G., Valenta R., Fiebig H., Kegel C., Disch R., Schmidt-Weber C. B., Blaser K., Akdis C. A.: Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J. Exp. Med. 2004, 11, 1567-1575.
  • 3. Bashir M. E., Andersen P., Fuss I. J., Shi H. N., Nagler-Anderson C.: An enteric helminth infection protects against an allergic response to dietary antigen. J. Immunol. 2002, 15, 3284-3292.
  • 4. Cooper P. J.: Can intestinal helminth infections (geohelminths) affect the development and expression of asthma and allergic disease? Clin. Exp. Immunol. 2002, 128, 398-404.
  • 5. Cooper P. J., Mancero T., Espinel M., Sandoval C., Lovato R., Guderian R. H., Nutman T. B.: Early human infection with Onchocerca volvulus is associated with an enhanced parasite-specific cellular immune response. J. Infect. Dis. 2001, 183, 1662-1668.
  • 6. Cywińska A., Baś M., Schollenberger A.: Heligmosomoides polygyrus infection in mice - a model for intestinal nematode parasitis. Medycyna Wet. 2004, 60, 673-784.
  • 7. Doetze A., Satoguina J., Burchard G., Rau T., Loliger C., Fleischer B., Hoerauf A.: Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by T(h)3/T(r)1-type cytokines IL-10 and transforming growth factor-beta but not by a T(h)1 to T(h)2 shift. Int. Immunol. 2000, 5, 623-630.
  • 8. Doligalska M., Borowik M. M.: Prognozowanie transmisji parazytoz wywołanych przez helminty. Medycyna Wet. 2004, 60, 227-231.
  • 9. Doligalska M., Rzepecka J., Drela N., Donskow K., Gerwel-Wronka M.: The role of TGF-β in mice infected with Heligmosomoides polygyrus. Parasite Immunol. 2006, w druku.
  • 10. Falcone F. H., Pritchard D. I.: Parasite role reversal: worms on trial. Trends Parasitol. 2005, 21, 157-160.
  • 11. Finkelman F. D., Shea-Donohue T., Goldhill J., Sullivan C. A., Morris S. C., Madden K. B., Gause W. C., Urban J. F.: Cytokine regulation of host defense against parasitic gastrointestinal helminthes: lessons from studies with rodent models. Ann. Rev. Immunol. 1997, 15, 505-533.
  • 12. Hesse M., Piccirillo C. A., Belkaid Y., Prufer J., Mentink-Kane M., Leusink M., Cheever A. W., Shevach E. M., Wynn T. A.: The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells. J. Immunol 2004, 172, 3157-3166.
  • 13. Holland M. J., Harcus Y. M., Riches P. L., Maizels R. M.: Proteins secreted by the parasitic nematode Nippostrongylus brasiliensis act as adjuvants for Th2 responses.Eur. J. Immunol. 2000, 30, 1977-1987.
  • 14. ISAAC. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet 1998, 351, 1225-1232.
  • 15. Larski Z.: Osiągnięcia w badaniach mechanizmów odporności. Medycyna Wet. 2006, 62, 123-126.
  • 16. Maizels R. M.: Infections and allergy-helminths, hygiene and host immune regulation. Curr. Opin. Immunol. 2005, 17, 656-661.
  • 17. Mosmman T., Sad S.: The expanding universe of T cell subsets: Th1, Th2 and more. Immunol. Today 1996, 17, 138-146.
  • 18. Oh J. W., Seroogy C. M., Meyer E. H., Akbari O., Berry G., Fathman C. G., Dekruyff R. H., Umetsu D. T.: CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. J. Allergy Clin. Immunol. 2002, 110, 460-468.
  • 19. Peisong G., Yamasaki A., Mao X. Q., Enomoto T., Feng Z., Gloria-Bottini F., Bottini E., Shirakawa T., Sun D., Hopkin J. M.: An asthma-associated genetic variant of STAT6 predicts low burden of ascaris worm infestation. Genes Immun. 2004, 5, 58-62.
  • 20. Strachan D. P.: Hay fever, hygiene, and household size. Br. Med. J. 1989, 299, 1259-1280.
  • 21. Pinelli E., Whithagen C., Fonville M., Verlaan A., Dormans J., van Loveren H., Nicoll G., Maizels R. M., van der Giessen J.: Persistent airway hyper-responsiveness and inflammation in Toxocara canis-infected BALB/c mice. Clin. Exp. Allergy 2005, 35, 826-832.
  • 22. Selassie F. G., Stevens R. H., Cullinan P., Jones P., Harris J., Ayres J. G., Newman Taylor A. J.: Total and specific IgE (house dust mite and intestinal helminths) in asthmatics and controls from Gondar, Ethiopia. Clin. Exp. Allergy 2000, 30, 356-358.
  • 23. Shea-Donohue T., Sullivan C., Finkelman F. D., Madden K. B., Morris S. C., Goldhill J., Pineiro-Carrero V., Urban J. F. Jr.: The role of IL-4 in Heligmosomoides polygyrus-induced alterations in murine intestinal epithelial cell function. J. Immunol. 2001, 15, 2234-2239.
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  • 26. Wang C. C., Nolan T. J., Schad G. A., Abraham D.: Infection of mice with the helminth Strongyloides stercoralis suppresses pulmonary allergic responses to ovalbumin. Clin. Exp. Allergy. 2001, 31, 495-503.
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  • 29. Wohlleben G., Trujillo C., Muller J., Ritze Y., Grunewald S., Tatsch U., Erb K.: Helminth infection modulates the development of allergen-induced airway inflammation. Int. Immunol. 2004, 16, 585-596.
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Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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