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2003 | 08 | 1 |

Tytuł artykułu

Damage to erythrocyte membrane caused by chlorophenoxyacetic herbicides

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
We studied the damage caused to erythrocyte membranes by chlorophenoxyacetic herbicides. An increase in haemolysis was observed. The compounds investigated caused lipid bilayer damage by lipid peroxidation, as well as an increase in membrane fluidity at the 16th carbon atom of fatty acids was observed. Metabolites caused damage to membrane proteins - the free SH group content was increased. Higher toxicity of metabolites compared to basic compounds was observed.

Wydawca

-

Rocznik

Tom

08

Numer

1

Opis fizyczny

p.25-30,fig.

Twórcy

autor
  • University of Lodz, Banacha 12-16, 90-247 Lodz, Poland
autor

Bibliografia

  • 1.Charles, J.M., Hanley, T.R., Wilson, R.D., van Ravenzwaay, B. and Bus, J.S. Developmental Toxicity Studies in Rats and Rabbits on 2,4- Dichlorophenokxyacetic Acid and Its Forms. Toxicol. Sci. 1 (2001) 121-31.
  • 2.Sulik, M. and Matus, A. The effect of a herbicide sodium salt of
  • 2,4-dichlorophenoxyacetic acid on gurein carcinoma. Roch. Akad. Med. Biochmst. 41 (1996) 347-362.
  • 3.Takagi S. Chronic toxicity of 2-methyl-4-chlorophenoxyacetic acid (MCPA) in mice. Tohoku J. Exp. Med. 160 (1990) 97-107.
  • 4.Nagyova, A. and Ginter, E. The influence of ascorbic acid on the hepatic cytochrome P-450, and glutathione in guinea-pig exposed to 2,4- dichlorophenol. Physiol. Res. 5 (1995) 301-305.
  • 5.Venkov, P., Topashka-Ancheva, M., Gergieva, M., Alexieva, V. and Karanov, E. Genotoxic effect of substituted phenoxyacetic acids. Arch. Toxicol. 9 (2000) 560-566.
  • 6.Bradberry, S.M., Watt, B.E., Proudfoot, A.T. and Vale, J.A. Mechanism of toxicity, clinical features, and management of acute chlorophenoxy herbicide poisoning: a review. J. Toxicol. Clin. Toxicol. 2 (2000) 111-122.
  • 7.Bukowska, B., Chajdys, A., Duda, W. and Duchnowicz, P. Catalase activity in human erythrocytes: effect of phenoxyherbicides and their metabolites. Cell Biol. Int. 10 (2000) 705-711.
  • 8.Oakes, D.J. and Poliak, J.K. The in vitro evaluation of the toxicides of three related herbicide formulations containing ester derivatives of 2,4,5-T and 2,4-D using sub-mitochondrial particles. Toxicology 1-3 (2000) 1-9.
  • 9.Kaioumova, D.F. and Khabutdinova, L.K. Cytogenic characteristics of herbicide production workers in Ufa. Chemosphere 9-12 (1998) 1755-1759.
  • 10.Faustini, A., Settimi, L., Pacifici, R., Fano, V., Zuccaro, P. and Forastiere, F. Immunological changes among farmers exposed to phenoxy herbicides: preliminary observations. Occup. Environ. Med. 9 (1996) 583-585.
  • 11.Hardell, L. and Eriksson, M. A case-study of non-Hodgkin lymphoma and exposure to pesticide. Cancer 6 (1999) 1353-1360.
  • 12.Stock, J. and Dormandy, T.L. The autooxidation of human red cell lipid induced hydrogen peroxide. Brit. J. Haemat. 20 (1971) 95-101.
  • 13.Koter M. Changes in erythrocyte membranes after fractioned hyperthermia. Cell Biol. Int. 17 (1993) 665-670.
  • 14.Koter, M. and Grzelińska, E. Interpretacja widm znaczników spinowych stosowanych w badaniach płynności lipidów błon. Zagadnienia Biofizyki Współczesnej 14 (1989) 103-122.
  • 15.Ellman, G. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82 (1959) 70-77.
  • 16.Duchnowicz, P., Koter, M. and Duda, W. Damage of erythrocyte by phenoxyacetic herbicides and their metabolites. Pest. Biochem. Physiol. 74 (2002) 1-7.
  • 17.Suwalsky, M., Benites, M., Villena, F., Aguilar, F. and Sotomayor, C.P. Interaction of 2,4-dichlorophenoxyacetic acid (2,4-D) with cell and model membranes. Biochim. Biophys. Acta 1285 (1996) 267-276.
  • 18.Han, S.K., Ichikawa, K. and Utsumi, H. Quantitative analysis for the enhancement of hydroxyl radical generation by phenols during ozonation of water. Wat. Res. 11 (1998) 3261-3266.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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