Preparation and properties of alkylphospholipid liposomes: A review

• Autorzy: Zeisig R. , Fichtner I. , Arndt D.
• Języki publikacji: EN

Abstrakty

EN

Alkylphospholipids are synthetic compounds with relatively simple structures combining amphiphilic character and anticancer properties. It is possible to prepare different types of liposomes from APL if a high amount of cholesterol and a charged component is added. The biological relevant properties can be changed by sterical stabilization of these vesicles by the incorporation of up to 10 mol% poly(ethylenglycol) derivatives of phosphoethanolamine. This incorporation increased the fixed aqueous layer thickness from 0.83 nm to 3.57 nm. As a result of this changed property the uptake of such liposomes by macrophages was reduced compared to liposomes without a sterical stabilization. APL liposomes are remarkably stable in buffer and in plasma. APL-liposomes are able to induce the release of tumoricidal factors like TNF and NO from different macrophage cell lines. The strongest release was induced by a synergistic action of liposomal APC and lipopolysaccharide. Sterical stabilization prevents such an activation process likely as a result of significantly reduced uptake and internalization by the macrophages. APL are highly therapeutically active in a number of hormone-independent human mammary carcinomas. Using the MaTu mammary carcinoma xenotransplanted to nude mice the sterically stabilized HPC-SUV have the strongest cancerostatic formulation.

Słowa kluczowe

EN

mammary carcinoma; human serum; phagocytosis; alkylphosphocholine; in vivo; alkylphospholipid; cytotoxicity; liposome; man; anticancer activity; macrophage activation; synthetic compound; therapeutic effect

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 1996
• Tom: 01
• Numer: 4
• Opis fizyczny: p.447-457

Twórcy

autor

Zeisig R.

• Max Delbruck Center for Molecular Medicine, R.-Rossle- Str.10, 13122 Berlin-Buch, Germany

autor

Fichtner I.

autor

Arndt D.

Bibliografia

• 1. Hirt, R. and Berchtold, R. Pharm. Acta Helv. 33 (1958) 349-56.
• 2. Zeisig R., Jungmann S., Arndt D., Schütt A. and Nissen E Anti-Cancer Drugs 4 (1993) 57-64.
• 3. Eibl, H. and Unger, C.in: Biologische Bedeutung der Phospholipide: Entwick-lung von hexadecylphosphocholin- Eine Substanz mit selektiv- antitumoralen Eigenschaften. Stuttgart, Schattauer, 1989.
• 4. Eibl, H. and Engel, J. in: Alkylphosphocholines: New drugs in cancer therapy. Prog. Exp Tumor Res. (Eibl, H., Hilgard P. and Unger, C.; Eds.) Karger, Basel., 1992, 1-5.
• 5. Phyong, NH., Thuong NT., Charbier, P. CR Hebd Acad. Sci. Paris, Ser C, (1978) 283-229.
• 6. Langen, P., Maurer, H.R., Brachwitz, H., Veit, A. and Vollgraf, C. Anticancer Res. 12 (1992) 2109-2112.
• 7. Kötting, J., Marschner, N.W., Unger, C. and Eibl, H. in: Alkylphosphocholines: New drugs in cancer therapy. Prog. Exp Tumor Res. (Eibl, H., Hilgard P. and Unger, C.; Eds.) Karger, Basel., 1992, 6-11.
• 8. Geilen, C.C., Haase, A., Wieder, T., Arndt, D., Zeisig, R. and Reutter, W. J. Lipid Res.35 (1994) 625-632.
• 9. Grunicke, H. and Hofmann, J. Pharmac. Ther. 55 (1992) 1-30.
• 10. Zeisig, R., Eue, I., Kosch, M., Fichtner, I. and Arndt, D. Biochim. Biophys. Acta, 1283 (1996) 177-184.
• 11. Kaufmann-Kolle Unger, C and Eibl, H. in: Alkylphosphocholines: New drugs in cancer therapy. Prog. Exp Tumor Res. (Eibl, H., Hilgard P. and Unger, C.; Eds.) Karger, Basel., 1992, 12-24.
• 12. Roerdink, F.H., Regts, J., Handel, T., Sullivan, S.M., Baldeschwieler, J.D. and Scherphof, G.L. Biochim. Biophys. Acta 980 (1989) 234-240.
• 13. Kirby, C., Clarke, J. and Gregoriadis, G. Biochem. J. 186 (1980) 591-598.
• 14. Woodle, M.C. and Lasic, D. Biochim. Biophys. Acta 1113 (1992) 171-199.
• 15. Arndt, D. Zeisig, R., Eue, I., Sternberg, B. and Fichtner, I. Breast Cancer Res. Treatm., submitted, 1996.
• 16. Lee, K.D., Hong, K. and Papahadjopoulos, D. Biochim. Biophys. Acta 1103 (1992) 185-197.
• 17. Shimada, K., Miyagishima, A., Sadzuka, Y., Nozawa, Y., Mochizuki, Y., Oshima, H. and Hirota, S. J. Drug Targeting 3 (1995) 283-289.
• 18. Unger, C. in Alkylphosphocholine und Analoga. Georg Thieme Verlag Stuttgart 1989.
• 19. Andreesen, R., Osterholz, J., Luckenbach, G.A., Costabel, U., Schulz, A., Speth, V., Munder, P.G., Löhr, G.W. J. Natl Cancer Inst. 72 (1984) 53-59
• 20. Zeisig, R., Rudolf, M., Eue, I. and Arndt, D. J. Cancer Res. Clin. Oncol. 121 (1995) 69-75.
• 21. Eue, I., Zeisig, R. and Arndt, D. J. Cancer Res. Clin. Oncol. 121 (1995) 350-356.
• 22. Zeisig, R., Arndt, D., Jungmann, S. and Daemen, T. Anticancer Res. 14 (1994) 1785-1790.
• 23. Lorsbach R.B., Murphy W.J., Lowenstein, C.J., Snyder, S.H. and Russell S.W. J. Biol. Chem. 268 (1993) 1908-1913.
• 24. Devine, D.V., Wong, K., Serrano, K., Chonn, A. and Cullies, P.R., Biochim. Biophys. Acta 1191, (1994) 43-51.
• 25. Kronberg, B., Dahlmann,A., Carlfors, J. and Karlsson J. J. Pharmaceut. Sciences 79, (1990) 667-671.
• 26. Huang, S.K. Stauffer, P.R., Hong, K. Guo, J.W., Phillips, T.L., Huang, A. and Papahadjopoulos, D. Cancer Res. 54, (1994) 2186-91.
• 27. Daleke, L.D., Hong, K., Papahadjopoulos, D. Biochim. Biophys. Acta 1024, (1992) 352-366
• 28. Lee, K.D., Hong, K., Papahjopoulos, D. Biochim. Biophys. Acta 1103 (1992) 185-197.
• 29. Roerdink, F.H., Regts, J., Handel, T., Sullivan, S.M., Baldeschwieler, J.D. and Scherphof, G.L. Biochim. Biophys. Acta 980 (1989) 234-240.
• 30. Lee, KD, Nir, S and Papahadjopoulos D. Biochemistry 32, (1993) 889-899.
• 31. Rooijen, N.V. J. Immunol. Meth. 124 (1989) 1-6.
• 32. Zeisig, R., Fichtner, I., Arndt, D. and Jungmann, S. Anti-Cancer Drugs 2 (1991) 411-417.
• 33. Unger, C., Damenz, W., Fleer, E.A.M., Kim, D.J., Breiser, A., Hilgard, P., Engel, J., Nagel, G. and Eibl, H. Acta Oncol. 28 (1989) 213-217.
• 34. Fichtner, I., Zeisig, R., Naundorf, H., Jungmann, S., Asongwe, G., Double, J.A. and Bibby M.C. Breast Cancer Res. Treatment 32 (1994) 269-279.
• 35. Fichtner, I., Nauendorf, H., Saul, G.J., Zschiesche, W. and Zeisig, R. Contrib. Oncol. 51 (1996) - in press.
• 36. Kaufmann-Kolle, P., Drevs, J., Berger, M.R.; Kötting, J., Marschner, N., Unger, C. and Eibl, H. Cancer Chemother. Pharmacol. 34 (1994) 393-398.
• 37. Ahmad, I., Filep, J., Prior, J.L., Janoff, A.S. and Mayhew, E. Gordon Research Conf. on Drug Carriers in Medicine & Biology, Ventura, CA, 1996.