Proliferation and apoptosis in the guinea pig adrenal cortex during postnatal development

• Autorzy: Kaczmarczyk D , Kmiec B.L. , Daczewska M. , Kmiec K.B.
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was to determine the relation between involution of the FZ and the proliferation and apoptosis of the adrenal cortex cells. The study was carried out with adrenal glands from guinea pigs aged 1, 3, 9, 14, 21, 35 and 90 days. Paraffin slices were stained with Mayer haematoxylin and eosin and with acid fuchsin. For the immunohistochemical reaction the Anti- -PCNA Clone PC10 (Dako) was used. Apoptosis evaluation was performed with use of the TUNEL method (Roche). The results support the theory of involution of the FZ cells realised mainly by way of apoptosis. Analysis of the distribution and number of PCNA-positive cells in the adrenal cortex on subsequent days of PD may also back up the migration theory of renewal of the adrenal cortex cells.

Słowa kluczowe

EN

adrenal cortex; proliferation; fetal zone; guinea pig; postnatal development; adrenal gland; apoptosis

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2004
• Tom: 63
• Numer: 3
• Opis fizyczny: p.333-335,fig.,ref.

Twórcy

autor

Kaczmarczyk D

• Medical University, Narutowicza 60, 90-136 Lodz, Poland

autor

Kmiec B.L.

autor

Daczewska M.

autor

Kmiec K.B.

Bibliografia

• 1. Blanco A, Monterde JG, Mendez A, Artacho-Perula E (2001) Stereological study of normal and apoptotic cell populations in the adrenal gland in calves. Cell Tiss Org, 169: 73–80.
• 2. Bocian-Sobkowska J (1999) Morphomertic study of the human suprarenal gland in the first postnatal year. Folia Morphol, 58: 275–284.
• 3. Bocian-Sobkowska J, Woźniak W, Malendowicz LK (1998) Postnatal involution of the human adrenal fetal zone: stereologic description and apoptosis. Endocr Res, 24: 969–973.
• 4. Kaczmarczyk D, Kmieć BL (2002) Organogeneza nadnerczy świnki morskiej w okresie postnatalnym. Ann Acad Med Lodz, 43: 9–17.
• 5. Kataoka Y, Ikehara Y, Hattori T (1996) Cell proliferation and renewal of mouse adrenal cortex. J Anat, 188: 375–381.
• 6. Mitani F, Mukai K, Miyamoto H, Suematsu M, Ishimura Y (1999) Development of functional zonation in the rat adrenal cortex. Endo, 140: 3342–3353.
• 7. Spencer SJ, Mesiano S, Lee JY, Jaffe RB (1999) Proliferation and apoptosis in the human adrenal cortex during the fetal and perinatal periods: implications for growth and remodeling. J Clin End Metabol, 84: 1110–1115.
• 8. Wolkersdörfer GW, Ehrhart-Bornstein M, Brauer S, Marx C, Scherbaum WA, Bornstein SR (1996) Differential regulation of apoptosis in the normal human adrenal gland. J Clin End Metabol, 81: 4129–4136.