Structural changes of mitochondria during free radical-induced apoptosis

• Autorzy: Wakabayashi T , Spodnik J.H.
• Języki publikacji: EN

Abstrakty

EN

The initial proposal for apoptosis stressed nuclear change (condensation of chromatin) and the intactness of intracellular organelles, including mitochondria, based on light and electron microscopic observations. However, data have accumulated to demonstrate that the opening of megachannels of mitochondrial membranes, resulting in the swelling of the organelles, notably by Ca²⁺ and free radicals, is the crucial step in the apoptotic processes of the cell. Application of fluorescent dyes to mitochondria, combined with flow cytometry, has made it possible to detect subtle changes in the structure and function of the organelles related to apoptosis. The present article overviews structural aspects of mitochondria related to apoptosis, including the free radical-induced formation of megamitochondria.

Słowa kluczowe

EN

mitochondrion; cell biology; fluorescent dye; structural change; flow cytometry; cellular function; free radical; apoptosis; mammalian cell

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2000
• Tom: 59
• Numer: 2
• Opis fizyczny: p.61-75,fig.

Twórcy

autor

Wakabayashi T

• Nagoya University School of Medicine, 65, Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan

autor

Spodnik J.H.

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