The level of endogenous DNA damage in lymphocytes isolated from blood is associated with the fluctuation of 17beta-estradiol concentration in the follicular phase of healthy young women

• Autorzy: Kapiszewska M. , Kalemba M. , Grzesiak A. , Kocemba K.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to evaluate whether the differences in plasma 17β-estradiol concentration in early and late follicular phases of the menstrual cycle can affect the level of endogenous DNA damage in lymphocytes assessed by comet assay, and whether the extent of this damage in the follicular phase is associated with the genotype of catechol-O-methyltransferase (COMT). The level of DNA damage was positively correlated with 17β-estradiol concentration only in the late follicular phase. Subjects with the COMT L/L homozygous mutated variant revealed more DNA damage as compared to individuals with the COMT wild-type and heterozygous (H/L+HH) genotype.

Słowa kluczowe

EN

catechol-O-methyltransferase; blood; woman; young woman; 17beta-estradiol; lymphocyte; risk; concentration; follicular phase; comet assay; endogenous DNA damage; hormone-related cancer; cancer; breast cancer

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2005
• Tom: 52
• Numer: 2
• Opis fizyczny: p.535-539,fig.,ref.

Twórcy

autor

Kapiszewska M.

• Jagiellonian University, Krakow, Poland

autor

Kalemba M.

autor

Grzesiak A.

autor

Kocemba K.

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