Dermatan sulfate remodeling associated with advanced Dupuytren's contracture

• Autorzy: Kozma E. M. , Glowacki A. , Olczyk K. , Ciecierska M.
• Języki publikacji: EN

Abstrakty

EN

Dermatan sulfate (DS) widespread as a component of extracellular matrix proteoglycans, is characterized by great bio-reactivity and remarkable structural heterogeneity due to distinct degrees of sulfation and glucuronosyl epimerization and different polymerization degrees. However, DS metabolism under various biological conditions is poorly known. Dupuytren’s contracture is a benign fibromatosis leading to complex remodeling of the palmar fascia structure and properties. However, it remains unclear whether the disease affects the structure of DS, which is the major tissue glycosaminoglycan. Thus the aim of the study was to examine the structure of the total DS in Dupuytren’s fascia. DS chains were extracted from 5 samples of normal fascia and 7 specimens of Dupuytren’s tissue by papain digestion followed by fractionation with cetylpyridinium chloride. Then, DS structure analysis was performed comprising the evaluation of its molecular masses and sensitivity to hyaluronidase and chondroitinase B. Dupuytren’s contracture is associated with significant remodeling of DS chain structure revealed by (1) a distinct profile of chain molecular masses characterized by the appearance of long size components as well as the increase in the content of small size chains; (2) a different glucuronosyl epimerization pattern connected with the enhanced content of glucuronate disaccharide blocks; (3) chain oversulfation. These structural alterations in total DS may modify the GAG interactions especially affecting collagen fibrillogenesis and growth factor availability. Thus, Dupuytren’s contracture associated DS remodeling may promote the phenomena typical for advanced disease: apoptosis and reduction in cell number as well as the appearance of dense pseudotendinous collagen matrix

Słowa kluczowe

PL

dermatan sulphate; proteoglycan; polymerization; epimerization; animal tissue; extracellular matrix; fibromatosis; palmar fascia structure; fibrous cord

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2007
• Tom: 54
• Numer: 4
• Opis fizyczny: p.821-830,fig.,ref.

Twórcy

autor

Kozma E. M.

• Medical University of Silesia, Jagiellonska 4, 41-200 Sosnowiec, Poland

autor

Glowacki A.

autor

Olczyk K.

autor

Ciecierska M.

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