Ultrastructural changes of Ehrlich ascites tumor cells after intraperitoneal recombinant human tumor necrosis factor-alpha administration

• Autorzy: Terlikowski S J , Sulkowski S.T.
• Języki publikacji: EN

Abstrakty

EN

Swiss albino male mice were inoculated intraperitoneally (i.p.) with Ehrlich ascites tumor (EAT) and treated i.p. with recombinant human tumor necrosis factor-α (rhTNF-) three time a week in doses of 5, 7.5 and 10μg for 2 weeks, respectively. The effect of the cytokine on EAT was evaluated by the rate of tumor growth inhibition and ultrastructural changes in EAT cell. After the applied doses of rhTNF-α, inhibition of tumor growth was found. The number of EAT cells decreased after 7.5 and 10μg of rhTNF-α (P<0.001). Ultrastructural study demonstrated a cytotoxic effect of the cytokine on EAT cells.

Słowa kluczowe

EN

Ehrlich ascites tumour; antitumour effect; tumour necrosis factor-alpha; man; ultrastructural change; cytokine; administration; intraperitoneal treatment; cell ultrastructure; tumour growth

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2001
• Tom: 45
• Numer: 2
• Opis fizyczny: p.211-218,fig.

Twórcy

autor

Terlikowski S J

• Medical Academy of Bialystok, Bialystok, Poland

autor

Sulkowski S.T.

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