Nicardipine diminished equinatoxin II-induced decrease of coronary flow in isolated rat and pig hearts

• Autorzy: Bunc M , Rozman J. , Vidmar A. , Rakovec P. , Drevensek G. , Budihna M.V. , Suput D.
• Języki publikacji: EN

Abstrakty

EN

Equinatoxin II (EqT II) is a basic, cardiotoxic polypeptide. The vasoconstrictory effect of the toxin on isolated porcine coronary arteries was diminished by nicardipine, an L-type calcium channel antagonist. A comparison was made of the effects of EqT II alone and EqT II in the presence of nicardipine on the coronary flow in porcine and rat hearts isolated according to Langendorff's method. In both models EqT II decreased coronary flow in a dose-dependent manner and there were no statistically significant differences between the two models (p>0.05). However, 1µM nicardipine diminished the effects of EqT II on coronary flow in isolated porcine hearts more than in isolated rat hearts (p<0.05). The results suggest that the activation of L-type calcium channels is one of the mechanisms involved in the lowering of coronary flow induced by EqT II.

Słowa kluczowe

EN

coronary flow; pig; cardiotoxic polypeptide; vasoconstrictory effect; coronary artery; L-type calcium channel; heart; pathophysiology; nicardipine; rat; toxin

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2002
• Tom: 07
• Numer: 2
• Opis fizyczny: p.355-357

Twórcy

autor

Bunc M

• Medical Center, Ljubljana, Slovenia

autor

Rozman J.

autor

Vidmar A.

autor

Rakovec P.

autor

Drevensek G.

autor

Budihna M.V.

autor

Suput D.

Bibliografia

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• 3. Lee, C., Chen, M. Y., Lue, M. H. and Ferlan, I. A. Coronary vasospazm as the primary cause of death due to equinatoxin, a toxic protein from Actinia equina. Toxicon 26 (1987) 586.
• 4. Drevenšek, G., Budihna, M. V., Šuput, D. and Bunc, M. Nicardipine dose dependently reduces the effect of equinatoxin II on coronary flow in isolated porcine heart. Eur. J. Physiol. 440 (2000) R 145-146.
• 5. Belmonte, G., Pederzolli, C., Maček, P. and Menestrina, G. Pore formation by sea anemone cytolysin equinatoxin II in red blood cells. J. Membr. Biol. 131 (1993) 11-22.