Dermal and oral toxicity of malathion in rats

• Autorzy: Tos-Luty S. , Obuchowska-Przebirowska D. , Latuszynska J. , Tokarska-Rodak M. , Haratym-Maj A.
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was the evaluation of dermal and oral toxicity of malathion based on the results of histopathologic and ultrastructural tests. The standard of the pesticide - IPO 460 Malathion was used in the study. The preparation was suspended in oil emulsion. The study was conducted on Wistar rats. Dermal toxicity was examined in 2 groups of experimental rats. The animals were applied 8 mg (1/100 LD50) and 16 mg (1/50 LD50) of the preparation on the tail skin for 4 hours daily for a period of 28 days. In the case of oral toxicity, a dose of 1/50 LD50 malathion was used. The amount of 1 ml (11.2 g) of the preparation was administered intragastrically by stomach tube for 28 days. In both experiments the control animals were administered only the emulsion used for suspending the pesticide. The following organs were subject to histopathologic and ultrastructural evaluation: liver, kidneys, heart and lungs. The histopathologic and ultrastructural changes observed showed various degrees of intensity according to the route of malathion administration and the size of the dose applied. Dermal application of the pesticide in a smaller dose did not cause histopathological changes in the organs of the animals, while the administration of a higher dose resulted in changes only in the liver. Changes on the ultrastructural level occurred in all organs and were dose-dependent. After oral administration of malathion, both histopathologic and ultrastructural changes observed in all organs were more intensified than after dermal application.

Słowa kluczowe

EN

occupational hazard; malathion; oral toxicity; organophosphorus pesticide; pesticide; occupational medicine; histopathology; rat; neurotoxic effect; ultrastructure; dermal toxicity

• Wydawca: -
• Czasopismo: Annals of Agricultural and Environmental Medicine
• Rocznik: 2003
• Tom: 10
• Numer: 1
• Opis fizyczny: p.101-106,fig.

Twórcy

autor

Tos-Luty S.

• Institute of Agricultural Medicine, P.O.Box 185, 20-950 Lublin, Poland

autor

Obuchowska-Przebirowska D.

autor

Latuszynska J.

autor

Tokarska-Rodak M.

autor

Haratym-Maj A.

Bibliografia

• 1. Akay MT, Elcuman A, Nurcan M, Kolankaya D, Yilmazoglu G: Bioavailability and toxicological potential of lentil-bound residues of malathion in rats. J Environ Sci Health B 1992, 27, 325-340.
• 2. Amer SM, Fahmy MA, Aly FA, Farghaly AA: Cytogenetic studies on the effect of feeding mice with stored wheat grains treated with malathion. Mutat Res 2002, 513, 1-10.
• 3. Cabello G, Valenzuela M, Vilaxa A, Duran V, Rudolph I, Hrepic N, Calaf G: A rat mammary tumor model induced by the organophosphorous pesticides parathion and malathion, possibly through acetylcholinesterase inhibition. Environ Health Perspect 2001, 109, 471- 479.
• 4. Chang SK, Williams PL, Dauterman WC, Riviere JE: Percutaneous absorption, dermatopharmacokinetics and related parathion in isolated perfused porcine skin. Toxicology 1994, 91, 269-280.
• 5. Królikowska-Prasał I, Kifer-Wysocka E, Matysiak W, Romanowska-Sarlej J: Morphologische Beurteilung und Analyse von Superelementen in der Leber von Ratten, die mit Kraftwerk-Aschen enthaltendem Futter gefuttert wurden. Gegenbaurs Morphol Jahrb Leibzig 1990, 136, 565-574.
• 6. Marrs TC, Dewhurst I: Toxicology of pesticides. In: Ballantyne B, Marrs TC, Syversen T: General and Applied Toxicology. MacMillan, London, New York 2000, 1993-1998.
• 7. Saleh MA, Ahmed AE, Kamel A, Dary C: Determination of the distribution of malathion in rats following various routes of administration by whole-body electronic autoradiography. Toxicol Ind Health 1997, 13, 751-758.
• 8. Syed MA, Arshad JH, Mat S: Biological activity and bioavailability of grain bound 14C malathion residues in rats. J Environ Sci Health B 1992, 27, 347-354.
• 9. Videira RA, Antunes-Madeira MC, Lopes VI, Madeira VM: Changes induced by malathion, methylparathion and parathion on membrane lipid physicochemical properties correlate with their toxicity. Biochim Biophys Acta 2001, 1511, 360-368.
• 10. Waldron Lechner D, Abdel-Rahman MS: Kinetics of carbaryl and malathion in combination in the rat. J Toxicol Environ Health 1986, 18, 241-256.
• 11. Zayed SM, Farghaly M, Mostafa IY: Bioavailability to rats and toxicological potential in mice of bound residues of malathion in beans. J Environ Sci Health B 1992, 27, 341-346.