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2007 | 10 | 1 |

Tytuł artykułu

Paraneoplastic autoimmunity

Autorzy

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Loss of homeostasis is a hallmark of malignant tumorigenesis and autoimmune diseases. Recent studies have implicated apoptotic cell death pathways in initiating and propagating autoimmune diseases in susceptible individuals. During malignancy, however, there is an accumulation of cells resistant to apoptosis. Intriguingly, some patients with malignant tumors develop symptoms that cannot be explained solely on the basis of the effects produced by either the primary tumor or its metastases. The mechanisms responsible for these complex symptoms, known as paraneoplastic autoimmunity, remain the focus of investigation.

Wydawca

-

Rocznik

Tom

10

Numer

1

Opis fizyczny

p.61-64,fig.,ref.

Twórcy

autor
  • Centre Viggo Petersen, Hopital Lariboisiere, 2, rue Ambroise Pare University Paris 7, F-75475 Paris Cedex 10, France

Bibliografia

  • Cho-Chung YS (2006) Autoantibody biomarkers in the de­tection of cancer. Biochim Biophys Acta 1762: 587-591.
  • Demaison C, Chastagner P, Theze J, Zouali M (1994) So­matic diversification in the heavy chain variable region genes expressed by human autoantibodies bearing a lu­pus-associated nephritogenic anti-DNA idiotype. Proc Natl Acad Sci USA 91: 514-518.
  • Gouin-Thibault I, Achkar A, Samama MM (2001) The thrombophilic state in cancer patients. Acta Haematol 106: 33-42.
  • Gronbaek K, Straten PT, Ralfkiaer E, Ahrenkiel V, Ander­sen MK, Hansen NE, Zeuthen J, Hou-Jensen K, Gul- dberg P (1998) Somatic Fas mutations in non-Hodgkin’s lymphoma: association with extranodal disease and autoimmunity. Blood 92: 3018-3024.
  • Levinson AI, Zheng Y, Gaulton G, Moore J, Pletcher CH, Song D, Wheatley LM (2003) A new model linking in- trathymic acetylcholine receptor expression and the pathogenesis of myasthenia gravis. Ann NY Acad Sci 998: 257-265.
  • Radic MZ, Zouali M (1996) Receptor editing, immune di­versification, and self-tolerance. Immunity 5: 505-511.
  • Ramos-Casals M, Trejo O, Garcia-Carrasco M, Cervera R, De La Red G, Gil V, Lopez-Guillermo A, Ingelmo M, Font J (2004) Triple association between hepatitis C vi­rus infection, systemic autoimmune diseases, and B cell lymphoma. J Rheumatol 31: 495-499.
  • Sakaguchi S (2000) Regulatory T cells: key controllers of immunologic self-tolerance. Cell 101: 455-458.
  • Schwartz RH (1989) Acquisition of immunologic self-toler­ance. Cell 57: 1073-1081.
  • Viau M, Zouali M (2005) B-lymphocytes, innate immunity, and autoimmunity. Clin Immunol 114: 17-26.
  • Zhang B, Zheng R, Wang J, Bu D, Zhu X (2006) Epitopes in the linker subdomain region of envoplakin recognized by autoantibodies in paraneoplastic pemphigus patients. J Invest Dermatol 126: 832-840.
  • Zouali M (2002) B cell diversity and longevity in systemic autoimmunity. Mol Immunol 38: 895-901.
  • Zouali M (2005) Taming Lupus. Sei Am 292: 70-77.
  • Zouali M, Fine JM, Eyquem A (1984) A human monoclonal IgGl with anti-idiotypic activity against anti-human thy- roglobulin autoantibody. J Immunol 133: 190-194.
  • Zouali M, Fine JM, Eyquem A (1984) Anti-DNA autoanti­body activity and idiotypic relationships of human mon­oclonal proteins. Eur J Immunol 14: 1085-1089.
  • Zouali M, Sarmay G (2004) B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment. Arthritis Rheum 50: 2730-2741.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-b065a66a-9a10-4db5-8064-293f18a74e35
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