Molecular modeling of singlet-oxygen binding to anthraquinones in relation to the peroxidating activity of antitumor anthraquinone drugs

• Autorzy: Liwo A. , Jeziorek D. , Ossowski T. , Dyl D. , Tempczyk A. , Tarasiuk J. , Nowacka M. , Borowski E. , Woznicki W.
• Języki publikacji: EN

Abstrakty

EN

Anthraquinone derivatives are important anti-cancer drugs possessing, however, undesirable peroxidating and, in consequence, cardiotoxic properties. This results from the mediation by these compounds of the one-electron reduction processes of the oxygen molecule, which produces the highly toxic superoxide anion radical and other active oxygen species. This article summarizes the results of our studies on the molecular aspects of the mechanism of anthraquinone-mediated peroxidation which were carried out using enzymatic-assay, electrochemical, and quantum-mechanical methods.

Słowa kluczowe

EN

active oxygen species; oxygen addition; antitumour drug; quantum mechanics; peroxidation; toxic superoxide anion radical; aromatic compound; anthracycline

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1995
• Tom: 42
• Numer: 4
• Opis fizyczny: p.445-456,fig.

Twórcy

autor

Liwo A.

• University of Gdansk, J.Sobieskiego 18, 80-952 Gdansk, Poland

autor

Jeziorek D.

autor

Ossowski T.

autor

Dyl D.

autor

Tempczyk A.

autor

Tarasiuk J.

autor

Nowacka M.

autor

Borowski E.

autor

Woznicki W.

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