Contradictory functions of sulfatide in the blood coagulation system as coagulant and anticoagulant

• Autorzy: Kyogashima M. , Onaya J. , Hara A. , Taketomi T.
• Języki publikacji: EN

Abstrakty

EN

Sulfatide (galactosylceramide I3 -sulfate) has been reported to activate blood coagulation factor XII (Hageman factor), which suggests that it exhibits coagulant activity (Fujikama et al., 1980 Biochemistry 19, 1322-1330) However, sulfatide administered into animals as a bolus shot without subsequent thrombus formation, prolonged conventional clotting times and bleeding time (Hara et al., 1996 Glycoconjugate J. 13, 187-194). These findings suggest that it may exhibit anticoagulant rather than coagulant activity. Following this suggestion we found in vitro that binding of sulfatide to fibrinogen resulted in disturbance of fibrin formation. To examine a possible pharmacological effect of sulfatide on blood coagulation in vivo we continuously infused sulfatide into rats through plastic cannulae and found formation of giant thrombi around the tips of the cannulae. These data suggest that sulfatide may exhibit contradictory functions in the blood coagulation system.

Słowa kluczowe

EN

coagulation factor; blood coagulation system; fibrinolytic agent; fibrinogen; in vivo; animal; sulphatide; rat; ovalbumin; coagulant

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1998
• Tom: 45
• Numer: 2
• Opis fizyczny: p.493-499,fig.

Twórcy

autor

Kyogashima M.

• Seikagaku Corporation Tokyo Research Institute Higashiyamato-shi, Tokyo 207-0021, Japan

autor

Onaya J.

autor

Hara A.

autor

Taketomi T.

Bibliografia

• 1. Wago, K. (1961) Antiatherosclerotic and anti­coagulant activity of cerebroside sulfate. Jpn. Heart J. 2, 354 -367.
• 2. Fujikawa, K., Heimark, R.L., Kurachi, K. & Davie, E.W. (1980) Activation of bovine factor XII (Hageman factor) by plasma kallikrein. Biochemistry 19, 1322-1330.
• 3. Mann, K.G., Jenny, R.J. & Krishnaswamy, S. (1988) Cofactor proteins in the assembly and expression of blood clotting enzyme com­plexes. Anna. Rev. Biochem. 57, 915-956.
• 4. Saito, H. (1994) The contact phase of blood co­agulation; in Haemostasis and Thrombosis (Bloom, A.L., Forbes, C.D., Thomas, D.P. & Tuddenham, E.G.D., eds.) 3rd. edn., pp. 289- 307, Churchill Livingstone, Edinburgh.
• 5. Schmaier, A.H. (1997) Contact activation: A revision. Thromb. Haemost. 78, 101-107.
• 6. Taketomi, T., Hara, A., Uemura, K. & Kyo­gashima, N. (1989) Effect of long-term treat­ment with sulfatide on hyperlipidemia and progression of atherosclerosis in WHHL rab­bits. Jpn. J. Exp. Med. 59, 221-231.
• 7. Zhu, X., Hara, A. & Taketomi, T. (1991) The existence of galactosylceramide I -sulfate in serums of various mammals and its anticoagu­lant activity. J. Biochem.ll0, 241-245.
• 8. Hara, A., Uemura, K. & Taketomi, T. (1996) Sulfatide prolongs blood-coagulation time and bleeding time by forming a complex with fi­brinogen. Glycoconjugate J. 13, 187-194.
• 9. Hara, A., Kutsukake, Y., Uemura, K. & Take­tomi, T. (1993) Anticoagulant activity of sulfa­tide and its anti-thrombotic effect in rabbit. J. Biochem. (Tokyo) 113, 781-785.
• 10. Bjork, I., Olson, S.T. & Shore, J.D. (1989) Mo­lecular mechanisms of the accelerating effect of heparin on the reactions between anti- thrombin and clotting proteinases; in Heparin (Lane, D.A. & Lindahl, U., eds.) pp. 229-255,Edward Arnold, London, Melbourne, Auck­land.
• 11. Thomson, J.M. & Poller, L. (1985) The acti­vated partial thromboplastin time; m Blood Coagulation end Haemostasis (Thomson, J.M., ed.) pp. 301-339, Churchill Livingstone, Edin­burgh, London, Melbourne, New York.
• 12. Bourin, M.-C. & Lindahl, U. (1993) Glycosami- noglycans and the regulation of blood coagula­tion. Biochem. J. 289, 313-330.
• 13. Hojima, Y., Cochrane, C.G., Wiggins, R.C., Austen, K.F. & Stevens, R.L. (1984) In vitro ac­tivation of the contact (Hageman factor) sys­tem of plasma by heparin and chondroitin sul­fate E. Blood 63, 1453-1459.
• 14. Tanaka, S. & Iwanaga, S. (1993) Limulus test for detecting bacterial endotoxins. Methods Enzymol 223, 358-364.
• 15. Magnani, J.L., Spitalnik, S.L. & Ginsburg, V. (1987) Antibodies against cell surface carbohy­drates: Determination of antigen structure. Methods Enz?mol 138, 195-207.
• 16. Broze, G.J., Jr. (1994) The tissue factor path­way of coagulation: Factor VII, tissue factor, and tissue factor pathway inhibitor; in Haemo- stasis and Thrombosis (Bloom, A.L., Forbes, C.D., Thomas, D.P. & Tuddenham, E.G.D., eds.) 3rd edn., pp. 349-377, Churchill Living­stone, Edinburgh.
• 17. Kyogashima, M., Onaya, I., Hara, A. & Take- tomi, I. (1998) Sulfatide can markedly en­hance thrombogenesis in rat deep vein throm­bosis model. Glycoconjugate J. (in press).
• 18 Hara, A. & Taketomi, T. (1987) Occurrence of sulfatide as a major glycosphingolipid in WHHL rabbit serum lipoproteins. J. Biochem. 102, 83-92.
• 19. Hara, A. & Taketomi, T. (1991) Characteriza­tion and changes of glycosphingolipids in the aorta of the Watanabe hereditable hyperlipi- demic rabbit J. Biochem. (Tokyo) 109, 904- 908.
• 20. Roberts, D.D. & Ginsburg, V. (1988) Sulfated glycolipids and cell adhesion. Arch. Biochem. Biophys. 267, 405-415.
• 21. Roberts, D.D., Rao, C.N., Magnani, J.L., Spi­talnik, S.L., Liotta, L.A. & Ginsburg, V. (1985) Laminin binds specifically to sulfated glycolip­ids. Proc. Natl Acad. ScL U.S.A. 82, 1306-1310.
• 22. Roberts, D.D., Haverstick, D.M., Dixit, V.M., Frazier, W.A., Santoro, S.A. & Ginsburg, V. (1985) The platelet glycoprotein thrombo- spondin binds specifically to sulfated glycolip­ids. J. Biol Chem. 260. 9405-9411.
• 23. Roberts, D.D., Williams, S.B., Gralnick, H.R. & Ginsburg, V. (1986) von Willebrand factor binds specifically to sulfated glycolipids. J. Biol Chem. 261, 3306-3309.
• 24. Holt, G.D., Krivan, H.C., Gasic, G.J. & Gins­burg, V. (1989) Antistasin, an inhibitor of co­agulation and metastasis, binds to sulfatide (Gal(3-S04y?l-lCer) and has a sequence homol­ogy with other proteins that bind sulfated gly- coconjugates. J. Biol Chem. 264, 12138- 12140.
• 25. Holt, G.D., Pangburn, M.K. & Ginsburg, V. (1990) Properdin binds to sulfatide (Gal(3- SO^) fil-lCer) and has a sequence homology with other proteins that bind sulfated glyco- conjugates. J. Biol Chem. 265, 2852-2855.
• 26. Suzuki., Y., Toda, Y., Tamatani, T., Kiso, M., Hasegawa, A., Tadano-Aritomi, K., Ishizuka, I. & Miyasaka, M. (1993) Sulfated glycolipids arc ligands for a lymphocyte homing receptor, L- selectin (LECAM-1), binding epitope in sul­fated sugar chain. Biochem. Biophys. Res. Comm. 190, 426-434.
• 27. Higashi, H., Suzuki, Y., Mukaida, N., Taka- hashi, N., Miyamoto, D. & Matsushima, K. (1997) Intervention in endotoxin shock by sul-fatide ( ISOg-GalCer) with a concomitant re­duction in tumor necrosis factor alpha produc­tion. Infect 1mmun. 65, 1223-1227.