The importance of HLA DQB1 0602 typing in Slovene patients with narcolepsy

• Autorzy: Dolenc-Grosel L , Vodusek D.B.
• Języki publikacji: EN

Abstrakty

EN

The HLA class II region genes DQB1*0602 and DQA1*0102 are currently the best genetic predictors for narcolepsy in humans [1], The aim of this study was to identify the HLA DQ alleles (DQB1*0602 and DQA1*0102) in Slovene sporadic narcoleptic patients. 11 patients who fulfilled ICSD criteria for narcolepsy entered the study. DRB1*1501 DQB1*0602 was present in all the patients while DQA1*0102 was absent in 2 patients. We propose that DQB1*0602 typing is important in diagnosing narcolepsy in Slovene patients.

Słowa kluczowe

EN

narcolepsy; patient; man; allele; neurophysiology

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2002
• Tom: 07
• Numer: 2
• Opis fizyczny: p.359-360

Twórcy

autor

Dolenc-Grosel L

• University Medical Centre, Ljubljana, Slovenia

autor

Vodusek D.B.

Bibliografia

• 1. Lin, L., Hungs, M. and Mignot, E. Narcolepsy and the HLA region. J. Neuroimmunol. 117 (2001) 9-20.
• 2. Guilleminault, C. Narcolepsy. In: The International Classification of Sleep Disorders: Diagnostic and Coding Manual. Diagnostic steering committee, (Thorpy MJ. Ed.) American sleep disorders association, Allen Press, Rochester 1990, 38-42.
• 3. Mignot, E., Young, T., Lin, L. and Finn, L. Nocturnal sleep and daytime sleepiness in normal subjects with HLA-DQB1*0602. Sleep 22 (1999) 347-352.