Lipid-based antifungal agents: a concise overview

• Autorzy: Arikan S
• Języki publikacji: EN

Abstrakty

EN

The development of lipid formulations of antifungal drugs has been a remarkable progress in the systemic antifungal arena. The lipid-based amphotericin B formulations; amphotericin B lipid complex (ABLC) amphotericin B colloidal dispersion (ABCD), and 1iposomal amphotericin B (L-AMB) have been in clinical use since the 1990s. They are significantly less nephrotoxic than the parent compound and can be safely used at higher doses. The primary cost of these formulations is significantly high and the extent of data related to their head-to-head comparison remains limited. The lipid formulation of nystatin, liposomal nystatin, is another lipid-based polyene under development. Available data concerning the in vitro activity, pharmacokinetic profile, in vivo efficacy, and safety of these formulations are summarized in this overview.

Słowa kluczowe

EN

amphotericin B colloidal dispersion; liposomal nystatin; development; antifungal agent; liposomal amphotericin B; lipid formulation; amphotericin B lipid complex

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2002
• Tom: 07
• Numer: 3
• Opis fizyczny: p.919-922

Twórcy

autor

Arikan S

• Hacettepe University Medical School, 06100 Ankara, Turkey

Bibliografia

• 1. Arikan, S. and Rex, J. H. Lipid-based antifungal agents: Current status. Curr. Pharmaceut. Des. 7 (2001) 393-415.
• 2. Arikan, S. and Rex, J. H. New agents for treatment of systemic fungal infections-Current status. Expert Opin. Emerg. Drugs 7 (2002) 3-32.
• 3. Storm, G. and van Etten, E. Biopharmaceutical aspects of lipid formulations of amphotericin B. Eur. J. Clin. Microbiol. Infect. Dis. 16 (1997) 64-73.
• 4. Wasan, K. M. and Lopez-Berestein, G. Diversity of lipid-based polyene formulations and their behavior in biological systems. Eur. J. Clin. Microbiol. Infect. Dis. 16 (1997) 81-92.
• 5. Arikan, S. and Rex, J. H. Nystatin LF. Curr. Opin. Invest. Drugs 2 (2001) 488-495.