The effect of tumor necrosis factor-alpha [TNF-alpha], interleukin [IL]-1beta and IL-6 on prostaglandins [PG]F2alpha and E2 secretion from maternal placenta in pigs

• Autorzy: Jana B. , Koszykowska M. , Andronowska A.
• Języki publikacji: EN

Abstrakty

EN

The aim of the present study was to determine the effect of tumor necrosis factor-α (TNF-α), interleukin-lß (IL-lß) and interleukin-6 (IL-6) on prostaglandin (PG)F2α and PGE2 secretion as well as on cyclooxygenase-2 (COX-2) protein expression in maternal placenta collected on days 25, 30 and 40 of pregnancy in pigs. Maternal placental slices were incubated for 16 h with TNF-α, IL-lß and IL-6 and (1 or 10 ng/ml of medium) or two combinations of the three cytokines (1 or 10 ng/ml of each cytokine per combination). We demonstrated the stimulatory effect of TNF-α, IL-lß and IL-6 and on PGF2α and PGE2 secretion by the porcine maternal placenta. The medium content of these PGs depended on the cytokine type, its concentration and day of pregnancy. Cytokine stimulation of PGE2 was more pronounced than that of PGF2α. Additionally, an increase in PGF2 and/or PGE2 secretion was usually associated with the augmentation of COX-2 protein expression. Our study shows that TNF-α, IL-lß and IL-6 increase production of PGF2α and PGE2 by porcine maternal placenta from 25, 30 and 40 day of pregnancy. These results further confirm the possible role of cytokines in modulating secretion of PGs by maternal placenta during the first trimester of gestation.

Słowa kluczowe

EN

pig; placenta; maternal placenta; cytokine; tumour necrosis factor-alpha; interleukin 1beta; interleukin 6; prostaglandin; secretion; cyclooxygenase-2; protein expression; pregnancy

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2008
• Tom: 11
• Numer: 4
• Opis fizyczny: p.315-322,fig.,ref.

Twórcy

autor

Jana B.

• Polish Academy of Sciences, Tuwima 10, 00-747 Olsztyn, Poland

autor

Koszykowska M.

autor

Andronowska A.

Bibliografia

• Arntzen KJ, Egeberg K, Rahimpoor S, Vatten L, Austgulen R (1999) LPS mediated production of IL-1, PGE2 and PGF2alpha from term decidua involves tumor necrosis factor receptor p55. J Reprod Immunol 45: 113-125.
• Arslan A, Zingg HH (1996) Regulation of COX-2 gene ex­pression in rat uterus in vivo and in vitro. Prostaglandins 52: 463-481.
• Ashworth MD, Ross JW, Hu J, White FJ, Stein DR, Desilva U, Johnson GA, Spencer TE, Geisert RD (2006) Ex­pression of porcine endometrial prostaglandin synthase during the estrous cycle and early pregnancy, and follow­ing endocrine disruption of pregnancy. Biol Reprod 74: 1007-1015.
• Astle S, Newton R, Thornton S, Vatish M, Slater DM (2007) Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour. Mol Hum Reprod 13: 69-75.
• Bazer FW, Vallet JL, Roberts RM, Sharp DC, Thatcher WW (1986) Role of conceptus secretory products in es­tablishment of pregnancy. J Reprod Fertil 76: 841-850.
• Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
• Burchard JF, Randall GC, Downey BR (1992) Production of prostaglandin by late-gestation porcine placental cells in vitro. J Reprod Fertil 95: 167-173.
• Chabot V, Lambert RD, Laforest JP, St-Jaques S, Matte JJ, Guay F, Pallin MF, Lessard M (2004) Effect of oestrous cycle and early pregnancy on uterine production and ex­pression of immune regulatory factors in gilts. Anim Rep­rod Sci 81: 137-149.
• Christenson LK, Farley DB, Anderson LH, Ford SP (1994) Luteal maintenance during early pregnancy in the pig: role for prostaglandin E2. Prostaglandins 47: 61-75.
• De M, Sanford TR, Wood GW (1992) Detection of inter­leukin 1, interleukin 6 and tumor necrosis factor alpha in the uterus during the second half of pregnancy in the mouse. Endocrinology 131: 14-20.
• Dudley DJ (1997) Pre-term labor: an intra-uterine inflam­matory response syndrome? J Reprod Immunol 30: 93- -109.
• Farina M, Ribeiro ML, Oganto D, Gimeno M. rrir.rr. .AM (2000) IL-1 alpha augments prostaglandin symhesrs ~ pregnant rat uteri by a nitric oxide mediated mechanism Prostaglandins Leukot Essent Fatty Acids 62: 243-2-“
• Hung TH, Chen SF, Hsu JJ, Hsieh CC, Hsueh S, Hsieh T7 (2006) Tumor necrosis factor-alpha converting enzyme in human gestational tissues from pregnancies compli­cated by chorioamniotis. Placenta 27: 996-1006.
• Hunt JS (1993) Expression and regulation of the tumor nec­rosis factor-h in the female reproductive tract. Reprod Fertil Dev 5: 141-153.
• Jana B, Kucharski J, Jedlinska-Krakowska M, Wolinska- -Witort E (2005) The effect of intrauterine infusion of inflammation-provoking factors on proinflammatory cytokines and hormones in rat peripheral blood. Pol J Vet Sci 4: 275-282
• Jana B, Kucharski J, Dzienis A, Deptula K (2007) Changes in prostaglandin production and ovarian function in gilts during endometritis induced by Escherichia coli infec­tion. Anim Reprod Sci 97: 137-150.
• Jana B, Kozlowska A, Andronowska A, Jedlinska- -Krakowska M (2008) The effect of tumor necrosis fac- tor-a (TNF-a), interleukin (IL)-1|3 and IL-6 on chor- ioamnion secretion of prostaglandins (PG)F2ol and E2 in pigs. Rep Biol 8: 57-68.
• Kim YJ, Ahn JJ, Woo BH (1998) The effect of cytokine mediators on prostaglandin inhibition by human decidual cells. Am J Obstet Gynecol 179: 146-149.
• Knight JW, Bazer FW, Thacher WW, Franke DE, Wallace DE (1977) Conceptus development in intact and unilat­erally hysterectomized-ovariectomized gilts: interre­lations among hormonal status, placental development, fetal fluids and fetal growth. J Anim Sci 44: 620-637.
• Kucharski J, Stefanczyk-Krzymowska S, Jana B (2008) Ab­sorption of proinflammatory cytokines from inflamed porcine uterus into the uterine venous blood - prelimi­nary data. Pol J Vet Sci 1: 9-16.
• Ledwozyw A, Kadziolka A (1989) Swine fetal membrane and myometrium lipids in ontogenesis (in Polish). Polskie Archiwum Weterynaryne 29: 93-105.
• Lee SH, Soyoola E, Chanmungan P, Hart S, Sun W, Zhong H, Liou S, Simmons D, Hwang D (1992) Selective ex­pression of mitogen-inducible cyclooxygenase in macro- phagas, stimulated with lipopolysaccharide. J Biol Chem 267: 25934-25938.
• Martin RL, Whittle WL, Hollway AC, Gyomorey S, Gibb W, Lye S, Challis JR (2002) Ontogeny and regulation of ovine placental prostaglandin E2 synthase. Biol Reprod 67: 868-873.
• Mitchell MD, Dudley DJ, Edwin SS, Schiller SL (1991) In­terleukin-6 stimulates prostaglandin production by hu­man amnion and decidual cells. Eur J Pharmacol 192: 189-191.
• Mitchell MD, Edwin S, Romero DJ (1990) Prostaglandin biosynthesis by human decidual cells: effects of inflam­matory mediators. Prostaglandins 41: 35-38.
• Mitchell MD, Edwin SS, Lundin-Schiller S, Silver RM, Smotkin D, Trautman MS (1993) Mechanism of inter­leukin-1 beta stimulation of human prostaglandin bio­synthesis: mediation via novel inducible cyclooxygenase. Placenta 14: 615-625.
• Neely DP, Kindahl H, Stabenfeldt GH, Edqvist LE, Hughes JP (1979) Prostaglandin release pattern in the mare: physiological, pathophysilogical, and therapeutic re­sponses. J Reprod Fertil (Suppl.) 27: 181-189.
• Parent J, Chapdelaine P, Sirois J, Fortier MA (2002) Ex­pression of microsomal prostaglandin E synthase in bov­ine endometrium: coexpression with cyclooxygenase type 2 and regulation by interferon-tau. Endocrinology 143: 2936-2943.
• Parent J, Fortier MA (2005) Expression and contribution of three different isoforms of prostaglandin E synthase in the bovine endometrium. Biol Reprod 73: 36-44.
• Peter AT, Bosu WTK (1987) Effects of intrauterine infec­tion on the function of the corpora lutea formed after first postpartum ovulation in dairy cows. Theriogenology 127: 593-609.
• Pollard JK, Thai D, Mitchell MD (1994) Mechanism of cytokine stimulation of prostaglandin biosynthesis in hu­man decidua. J Soc Gynecol Investig 1: 31-36.
• Rajasingam D, Bennet PR, Alvi SA, Elder MG, Sullivan HF (1998) Stimulation of prostaglandin production from in­tact human fetal membranes by bacteria and bacterial products. Placenta 19: 301-306.
• Rice GE, Christensen P, Dantzer V, Skadhauge E (1989) Gestational profile of prostaglandin E2 synthesis by por­cine placenta and fetal membranes. Eicosanoids 2: 235- -240.
• Romero R, Mazor M, Wu YK, Avila C, Oyarzun E, Mitchell MD (1989) Bacterial endotoxin and tumor necrosis factor stimulate prostaglandin production by human decidua. Prostaglandins Leukot Essent Fatty Acids 37: 183-186.
• Shoji T, Yoshida S, Mitsunari M, Miyake N, Tsukihara S, Iwabe T, Harada T, Terakawa N (2007) Involvement of p38 MAP kinase in lipopolysaccharide-induced produc­tion of pro- and anti-inflammatory cytokines and prostag­landin E(2) in human choriodecidua. J Reprod Immunol 75: 82-90.
• Skarzynski DJ, Okuda K (2000) Different actions of norad­renaline and nitric oxide on the output of prostaglandins and progesterone in cultured bovine luteal cells. Prostag­landins Other Lipid Mediat 60: 35-47.
• Sooranna SR, Grigsby PL, Engineer N, Liang Z, Sun K, Myatt L, Johnson MR (2006) Myometrial prostaglandin E2 synthetic enzyme mRNA expression: spatial and tem­poral variations with pregnancy and labour. Mol Hum Reprod 12: 625-631.
• Splichalova A, Spihal I, Trebichavsky I, Hojn H (2004) Ex­pression of inflammatory markers in pig amnion after in- traamniotic infection with nonpathogenic or en- teropathogenic Escherichia coli. Folia Microbiol 49: 751- -756.
• Steiborn A, Geisse M, Kaufmann M (1998) Expression of cytokine receptors in the placenta in term and preterm labour. Placenta 19: 165-170.
• Tabibzadeh S (1991) Human endometrium: an active site of cytokine production and action. Endoc Rev 12: 272-290.
• Trebichavsky I, Spichal I, Zahradnickova M, Spichalova A, Mori Y (2002) Lipopolysaccharide induces inflammatory cytokines in the pig amnion. Vet Immunol Im- munopathol 87: 11-18.
• Xia HF, Sun QH, Peng JP (2007) Effect of interferon- -gamma treatment on the expression of interleukin-lbeta at the maternal-fetal interface of pregnant rats. Reprod Fertil Dev 19: 510-519.
• Yu Z, Gordon JR, Kendall J, Tacker PA (1998) Elevation in tumor necrosis factor-alpha (TNF-alpha) messenger RNA levels in the uterus of pregnant gilts after oestrogen treatment. Anim Reprod Sci 50: 57-67.