Elaboration and specific properties of fluorinated liposomes and related supramolecular systems

• Autorzy: Krafft M. P. , Riess J.G.
• Języki publikacji: EN

Abstrakty

EN

A range of well defined, pure, highly surface-active but non-hemolyzing fluorinated amphiphiles has recently been synthesized. Fluorocarbon chains strongly enhance the hydrophobic effect that induces the organization of amphiphiles into bilayer membranes, and supplement it with a lipophobic effect as well. This leads to an augmented tendency for fluorinated amphiphiles to selfassemble into vesicles (liposomes), tubules and other supramolecular aggregates when dispersed in water and other solvents. Fluorinated bilayers and vesicles are generally more stable and less permeant than those made from hydrocarbon analogs. The presence of a fluorinated film inside the liposomal membrane also has significant repercussions on the behavior of the liposomes in a biological milieu and on their in vivo recognition.

Słowa kluczowe

EN

lipophobic effect; liposome; fluorinated amphiphile; in vivo recognition; tubule; fluorocarbon chain; membrane; supramolecular system; drug delivery system; hydrophobic effect; vesicle; amphiphile

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 1996
• Tom: 01
• Numer: 4
• Opis fizyczny: p.459-468,fig.

Twórcy

autor

Krafft M. P.

• Universite de Nice-Sophia Antipolis, 06108 Nice Cedex 02, France

autor

Riess J.G.

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