Lymphocyte labile iron pool, plasma iron, transferrin saturation and ferritin levels in colon cancer patients

• Autorzy: Gackowski D. , Kruszewski M. , Banaszkiewicz Z. , Jawien A. , Olinski R.
• Języki publikacji: EN

Abstrakty

EN

Patients with colorectal carcinoma showed statistically significant lower values of transferrin saturation, total iron binding capacity and serum iron level as compared with control group, while the level of ferritin and the size of labile iron pool in carci­noma patients were higher, although this difference was not statistically significant. Our observations are in favour of the hypothesis which suggests that changes in iron metabolism restrict iron availability for tumour cells and as consequence, slow their growth.

Słowa kluczowe

EN

transferrin saturation; iron metabolism; patient; iron level; serum; colorectal carcinoma; labile iron pool; colon; cancer

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2002
• Tom: 49
• Numer: 1
• Opis fizyczny: p.269-272

Twórcy

autor

Gackowski D.

• Medical University in Bydgoszcz, M.Karlowicza 24, 85-092 Bydgoszcz, Poland

autor

Kruszewski M.

autor

Banaszkiewicz Z.

autor

Jawien A.

autor

Olinski R.

Bibliografia

• 1.Halliwell, B.M. & Gutterige, J.M.C. (1999) Free Radicals in Biology and Medicine; 3rd edn. Oxford University Press Inc., New York.
• 2.Stevens, G., Graubard, B.I., Micozzi, M.S., Neriishi, K. & Blumberg, B.S. (1994) Moderate elevation of body iron level and increased risk of cancer occurrence and death. Int. J. Cancer. 56, 364-369.
• 3.Nelson, R.L., Davis, F.G., Sutter, E., Sobin, L.H., Kikendall, J.W. & Bowen, P. (1994) Body iron stores and risk of colonic neoplasia. J. Natl. Cancer Inst. 86, 455-460.
• 4.Bird, C.L., Witte, J.S., Swendseid, M.E., Shikany, J.M., Hunt, I.F., Frankl, H.D., Lee, E.R, Longnecker, M.P. & Haile, R.W. (1996) Plasma ferritin, iron intake, and the risk of colorectal polyps. Am. J. Epidemiol. 144, 34-41.
• 5.Schmielau, J. & Finn, O.J. (2001) Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanisms of suppression of T-cell function in advanced cancer patients. Cancer Res. 61, 4756-4760.
• 6.Gackowski, D., Ciecierski, M., Jawien, A. & Olinski, R. (2001) Background level of 8-oxo-2'-deoxyguanosine in lymphocyte DNA does not correlate with concentration of antioxidant vitamins in blood plasma. Acta Biochim. Polon. 48, 535-539.
• 7.Epsztejn, S., Kakhlon, O., Glickstein, H., Breuer, W. & Cabantchik, I. (1997) Fluorescence analysis of the labile iron pool of mammalian cells. Anal. Biochem. 248, 31-40.
• 8.Lipinski, P., Drapier, J.-C., Oliveira, L., Retmanska, H., Sochanowicz, B. & Kruszewski, M. (2000) Intracellular iron status as a hallmark of mammalian cell susceptibility to oxidative stress: A study of L5178Y mouse lymphoma cell lines differentially sensitive to H2O2. Blood. 95, 2960-2966.
• 9.Stevens, R.G., Jones, D.Y., Micozzi, M.S. & Taylor, P.R. (1998) Body iron stores and the risk of cancer. N. Engl. J. Med. 319, 1047-1052.
• 10.Knekt, P., Reunanen, A., Takkunen, H., Aromaa, A., Heliovaara, M. & Hakulinen, T. (1994) Body iron stores and risk of cancer. Int. J. Cancer 56, 379-382.
• 11.Bendich, A. & Cohen, M. (1990) Ascorbic acid safety: Analysis of factors affecting iron absorption. Toxicol. Lett. 51, 189-201.
• 12.Hallberg, L., Hulten, L. & Gramatkovski, E. (1997) Iron absorption from the whole diet in men: How effective is the regulation of iron absorption? Am. J. Clin.. Nutr. 66, 347-356.
• 13.Ponka, P. (2000) Iron metabolism: Physiology and pathophysiology. J. Trace Elem. Exp. Med. 13, 73-93.
• 14. Weinberg, E.D. (1996) The role of iron in cancer. Eur. J. Cancer Prevent. 5, 19-36.