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Czasopismo

2003 | 62 | 3 |

Tytuł artykułu

A preliminary study of the submandibular gland of the rat after long-term cadmium intoxication

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of the study was to establish to what degree the 24-week exposure of a rat to 5 and 50 mg Cd/dm³ affects the proliferating activity of cells with PCNA and Ki-67 nuclear immunoreactivity in the submandibular gland cells. The control animals received only redistilled water to drink. The group I rats were given 5 mg Cd/dm³, while the group II animals were given 50 mg Cd/dm³. The highest concentration of cadmium was observed in group II, with a concomitant increase in the number of PCNA-positive cells. In group I, cadmium concentration was significantly less compared to group II, and there were fewer PCNA-positive cells. The reaction for Ki-67 in both experimental groups was negative.

Wydawca

-

Czasopismo

Rocznik

Tom

62

Numer

3

Opis fizyczny

p.305-307,fig.,ref.

Twórcy

autor
  • Medical University, Kilinskiego 1, 15-089 Bialystok, Poland
autor
autor
autor

Bibliografia

  • 1. Abdollahi M, Dehpour A, Kazemian P (2000) Alteration by cadmium of rat submandibular gland secretory function and the role of the 1 -arginine/nitric oxide pathway. Pharmacol Res, 42: 591–597.
  • 2. Chiarenza A, Elverdin JC, Espinal E, Giglio MJ (1989) Effects of kadmium on the function and structure of the rat salivary glands. Arch Oral Biol, 34: 999–1002.
  • 3. Gonzalez M, Banderas JA, Baez A, Belmont R (1997) Salivary lead and cadmium in a young population residing in Mexico city. Toxicol Lett, 93: 55-64.
  • 4. Menegario AA, Packer AP, Gine MF (2001) Determination of Ba, Cd, Cu, Pb and Zn in saliva by isotope dilution direct injection inductively coupled plasma mass spectrometry. Analyst, 126: 1363–1366.
  • 5. Scholzen T, Gerdes J (2000) The Ki-67 protein: from the known and the unknown. J Cell Physiol, 182: 311–322.
  • 6. Shivji KK, Kenny MK, Wood RD (1992) Proliferating cell nuclear antigen is required for DNA excision repair. Cell, 69: 367–374.
  • 7. Wormser U, Calp D (1988) Metallothionein induction by cadmium and zinc in rat sercretory organs. Experientia, 44: 754–755.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-a7ce67eb-a5e4-40e3-a76c-e0320fe9a14c
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