Activity of lysosomal exoglycosidases of rat alimentary tract in chronic exposure to N-nitrosodimethylamine

• Autorzy: Rostkowska K. , Zwierz K. , Arciuch L.P. , Rozanski A. , Moniuszko-Jakoniuk J. , Roszczenko A.
• Języki publikacji: EN

Abstrakty

EN

There is observed increasing pollution of environment by nitrosocompounds. Acute intoxication of animals by nitrosocompounds lead to necrosis and chronic exposure to neoplasm. We have little information on the influence of nitrosocompounds on metabolism of glycoconjugates (glycoproteins, glycolipids and proteoglycans) in animals. The aim of our work is evaluation the influence of exposure of rats for 10 and 90 days to N-nitrosodimethylamine (NDMA), on activity of lysosomal exoglycosidases (enzymes hydrolysing terminal sugars in oligosaccharides) in the alimentary tract. It was found that intoxication of rats with NDMA increased specific activity of N-acetyl-b-hexosaminidase, b-galactosidase and a-mannosidase in majority of tissues of rat alimentary tract. Damage the cells of alimentary tract by NDMA or its metabolites, increase activity of exoglycosidases, because damaged tissue elements must be removed by catabolic enzymes before restoration processes can start.

Słowa kluczowe

EN

activity; N-nitrosodimethylamine; exoglycosidase; gastrointestinal tract; rat; chronic exposure

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 1998
• Tom: 07
• Numer: 5
• Opis fizyczny: p.313-316,fig.,ref.

Twórcy

autor

Rostkowska K.

• Medical Academy in Bialystok, Adama Mickiewicza 2a, 15-222 Bialystok, Poland

autor

Zwierz K.

autor

Arciuch L.P.

autor

Rozanski A.

autor

Moniuszko-Jakoniuk J.

autor

Roszczenko A.

Bibliografia

• 1.ZWIERZ K., GINDZIENSKI A., OSTROWSKA L., STAN- KIEWICZ-CHOROSZUCHA B. Metabolism of glycoconju­gates in human gastric mucosa. Acta Med. Hung. 46, 275, 1989.
• 2.ZWIERZ K., JUSZKIEWICZ J., ARCIUCH L., GINDZIEN SKI A. N-acetyl-P-D-hexosaminidase - enzyme Tay-Sachss and Sandhoffs diseases. Post. Biochem. 38, 127, 1992.
• 3.OSTROWSKA L., ZWIERZ K., KONIUSZ Z., GINDZIEN SKI A. Function, properties and clinical significance ofN-ace- tyl-P-hexosaminidase. Post. Hig. Med. Dosw. 47, 67, 1993.
• 4.ARCIUCH L.P., OMASTA A., ROSTKOWSKA K., GALA- ZYN-SIDORCZUK M., MONIUSZKO-JAKONIUK I., ZWIERZ K. Influence of ethanol on the activity of glycosida ses in rats exposed to cadmium (Cd2+). Acta Biochim. Pol. 42, 297, 1995.
• 5.ZWIERZ K., MIDRO A.T. Inborn errors of metabolism in the carbohydrate-deficient glycoprotein syndrome (CDG). Post. Hig. Med. DoSw. 51, 205, 1997.
• 6.KARLOWSKI K. Wystepowanie zwiazk6w N-nitrozowych w zywnosci i tworzenie sie ich w warunkach in vivo. Roczn. PZH, 36, 4, 1985.
• 7.Institute of Food Technologists Expert on Panel on Food Safe ty, Nutrition: Potential mechanisms for food-related carcino gens and anticarcinogens. Food Technology, 47, 105, 1993.
• 8.NIKONOROW M., URBANEK-KARLOWSKA B. Nitrozoa- miny. in: Toksykologia zywnosci; PZWL: Warszawa, pp 270-281, 1987.
• 9.BELINSKY S.A., DEVEREUX T.R., ANDERSON M.W. Ro le of DNA methylation in the activation of proto-oncogenes and the induction of pulmonary neoplasia by nitrosamines. Mutation Res. 233, 105, 1990.
• 10.BRENDLER S.Y., TOMPA A., HUTTER K.F., PREUS­SMANN R., POOL-ZOBEL B.L. In vivo and in vitro genoto- xicity of several N-nitrosamines in extrahepatic tissues of the rat. Carcinogenesis, 13, 2435, 1992.
• 11.PREUSSMANN R., WIESSLER M. The enigma of organ spe cificity of carcinogenic nitrosamines. Trends Pharmacol. 8, 185, 1987.
• 12.SCHMITZ-MOORMAN P., GEDIGK P., DHARAMAD- HACH A. Early histological and histochemical changes du ring experimental production of liver carcinoma by diethylnit- rosamine. Z. Krebsforsch, 77, 9, 1972.
• 13.LIJINSKY W., EPSTEIN S.S. Nitrosamines as environmental carcinogenes. Nature, 255, 21, 1970.
• 14.STE1NKA I., PRZYBYLOWSKI P. Wptyw czynnikow bio­gennych na tworzenie N-nitrozoamin. Roczn. PZH, 42, 239, 1991.
• 15.SZUMILAK K. Mechanizm tworzenia sie N-nitrozoamin. Bromat. Chem. Toksykol., 1, 16, 1983.
• 16.CHATTERIEE S., VELICER L.F., SWEELEY C.C. Glycosp- hingolipid glycosyl hydrolases and glycosidases of synchroni zed human KB cells. J. Biol. Chem., 250, 4972, 1975.
• 17.ZWIERZ K., GINDZIENSKI A., GLOWACKA D., POROW­SKI T. The degradation of glycoconjugates in the human gast ric mucous membrane. Acta Med. Acad. Sci. Hung. 38, 145, 1981.
• 18.LOWRY O.H., ROSEBNROUGH N.J., FARR A.L., RAN DALL R.J. Protein measurement with Folin phenol reagent. J. Biol. Chem. 193, 265, 1951.
• 19.HANKE J., PIOTROWSKI J.K. Biochemiczne podstawy tok­sykologii; PZWL: Warszawa, pp 17-21, 63, 1984.
• 20.DE ROBERTIS E.D.P., NOWINSK1 W.W., SAEZ F.A. Prze- puszczalnosc komorki, fagocytoza, pinocytoza, lizosomy. in: Biologia komorki; PWN: Warszawa, pp 500-527, 1974.
• 21.HANKE J. Wplyw lekow i trucizn na synteze i aktywnosc enzymow mikrosomalnych uczestniczacych w ich przemianie. Folia Med. Cracov. 22, 263, 1980.
• 22.BRZOZOWSKI R. Nieswoiste i swoiste zapalenia jelit. in: Gastroenterologia kliniczna, S. Konturek ed.; PZWL: Warsza­wa, pp 359-386, 1980.
• 23.CZECZOT H., TUDEK B. Wplyw zwiazkow alkilujacych na indukcje zaberrowanych krypt w jelicie grubym szczurow rasy Wistar i myszy rasy Swiss. Bromat. Chem. Toksykol., 28, 79, 1995.
• 24.SIEGEL A., KAMIŃSKI M. Toksyczna smierc komorki. Acta Pol. Toxicol. 2, 12, 1994.
• 25.STEINKA I., PRZYBYLOWSKI P. Wplyw czynnikow bio­gennych na tworzenie sie N-nitrozoamin. Roczn. PZH, 42, 42, 1991.
• 26.ZAKRZEWSKI S.F. Podstawy toksykologii srodowiska; PWN: Warszawa, pp 45-66, 1995.
• 27.TU Y.Y., YANG C.S. Demethylation and denitrosation of nit- rosamines by cytochrome P-450 isozymes. Arch. Biochem. Biophys. 242, 32, 1985.
• 28.GUENGERICH F.P., SHIMADA T. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzy­mes. Chem. Res. Toxicol., 4, 391, 1991.
• 29.LABUC G.E., ARCHER M.C. Esophageal and hepatic mic rosomal metabolism of N-nitromethylbenzylamine and N-nit- rosodimethylamine in the rat. Cancer Res., 42, 3181, 1982.
• 30.CRADDOCK V.M. The pattern of methylated purines formed in DNA of intact and regenerating liver of rat treated with the carcinogen dimethylnitrosamine. Biochem. Biophys. Acta, 312, 202, 1973.
• 31.PALUT D. Wybrane mechanizmy kancerogenezy chemicznej. Roczn. PZH, 37, 89, 1986.
• 32.LUTZ W. Mikrosomalne cytochromy P-450 komorek wajrobowych a ksenobiotyki przemyslowe i srodowiskowe. Post. Hig. Med. Dosw. 38, 451, 1984.
• 33.LUTZ W., SZESZKO A., STANKIEWICZ A. Czy cytochrom P-450 zalezny system mikrosomalnych monooksygenaz chroni organizm przed toksycznym dziataniem ksenobiotykow? Pol. Tyg. Lek. 43, 34, 1988.