Wykorzystanie nerek transgenicznych swin do przeszczepow allogenicznych i ksenogenicznych

• Autorzy: Skucinski J , Nowak W. , Wieczorek J. , Solecki R.

Warianty tytułu

EN

Use of kidney transgenic pigs to allogenic and xenogenic transplantation

• Języki publikacji: PL

Abstrakty

EN

In the conducted study the possibility of using the transgenic pig kidneys for allogenic and heterogenic transplantation was evaluated with regards to the clinical context. There were 3 nontransgenic and 6 transgenic pig donors with a human α1.3-fukosylotransferase gene. The recipient of the kidneys were 6 nontransgenic and 3 transgenic pigs. The kidneys were heterotopic transplantated to intraperitoneal space. The kidney was transplanted to the left side at the level of 4-5 lumbar vertebra with end-to-side anastomosis of the renal vein and artery with vena cava caudale and aorta, respectively. The proposed surgical model of homological transplantation of kidneys in pigs allows for rapid organ collection without disturbing the structure, with continuous and tight vessel. The immunological response on the base of the changed levels of IL-1, IL-4 IL-6 IL-10 TNF-α and INF-γ in the serum were investigated. The acute immunological rejection of the graft was found on cell and humoral bases. There was a weaker immunological response after the transplantation of transgenic kidneys in comparison to nontransgenic ograns. Transgenesis has a positive effect on the immunological response.

Słowa kluczowe

PL

swinia; nerki; przeszczepianie narzadow; zwierzeta transgeniczne; przeszczepy allogeniczne; przeszczepy ksenogeniczne; ksenotransplantacje; transplantologia; narzady wewnetrzne

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2007
• Tom: 63
• Numer: 08
• Opis fizyczny: s.941-945,rys.,tab.,bibliogr.

Twórcy

autor

Skucinski J

• Uniwersytet Jagiellonski, ul.Kopernika 40, 31-501 Krakow

autor

Nowak W.

autor

Wieczorek J.

autor

Solecki R.

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