Endoplasmic reticulum quality control and apoptosis

• Autorzy: Groenendyk J. , Michalak M.
• Języki publikacji: EN

Abstrakty

EN

The ER is one of the most important folding compartments within the cell, as well as an intracellular Ca2+ storage organelle and it contains a number of Ca2+ regulated molecular chaperones responsible for the proper folding of glycosylated as well as non-glycosylated proteins. The luminal environment of the ER contains Ca2+ which is involved in regulating chaperones such as calnexin and calreticulin, as well as apoptotic proteins caspase-12 and Bap31, which may play an important role in determining cellular sensitivity to ER stress and apoptosis. The ER quality control system consists of several molecular chaperones, including calnexin, that assist in properly folding proteins and transporting them through the ER as well as sensing misfolded proteins, attempting to refold them and if this is not possible, targeting them for degradation. Accumulation of misfolded protein in the ER leads to activation of genes responsible for the expression of ER chaperones. The UPR mechanism involves transcriptional activation of chaperones by the membrane-localized transcription factor ATF6, in conjunction with the ER membrane kinase IRE1, as well as translational repression of protein synthesis by another ER membrane kinase PERK. When accumulation of misfolded protein becomes toxic, apoptosis is triggered, potentially with IRE1 involved in signaling via caspase-12. Both the extrinsic and intrinsic apoptotic pathways appear to culminate in the activation of caspases and this results in the recruitment of mitochondria in an essential amplifying manner. Bap31 may direct pro-apoptotic crosstalk between the ER and the mitochondria via Ca2+ in conjunction with caspase-12 and calnexin. Accordingly, ER stress and the resultant Ca2+ release must be very carefully regulated because of their effects in virtually all areas of cell function.

Słowa kluczowe

EN

intracellular organelle; endoplasmic reticulum; molecular chaperone; apoptosis; quality control

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2005
• Tom: 52
• Numer: 2
• Opis fizyczny: p.381-395,fig.,ref.

Twórcy

autor

Groenendyk J.

• University of Alberta, Edmonton, Alberta, Canada T6G 2H7

autor

Michalak M.

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