Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma

• Autorzy: Drzewiecka A. , Urbanska K. , Matuszak Z. , Pineiro M. , Arnaut L.G. , Habdas J. , Ratuszna A. , Stochel G.
• Języki publikacji: EN

Abstrakty

EN

We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emis­sion properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were examined following the growth of SKMEL 188 (human melanoma) cells irradiated with red light (cut off < 630 nm). The surviving frac­tion of the cells decreased about 3-fold (us. non-irradiated cells) for an 81 J/cm dose. Our results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy.

Słowa kluczowe

EN

biological effect; tritolylporphyrin dimer; photodynamic therapy; tumour; porphyrin; melanoma

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 1
• Opis fizyczny: p.277-282,fig.

Twórcy

autor

Drzewiecka A.

• Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland

autor

Urbanska K.

autor

Matuszak Z.

autor

Pineiro M.

autor

Arnaut L.G.

autor

Habdas J.

autor

Ratuszna A.

autor

Stochel G.

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