Effect of pesticides kynurenic acid production in rat brain slices

• Autorzy: Zielinska E. , Kocki T. , Saran T. , Borbely S. , Kuc D. , Vilagi I. , Urbanska E.M. , Turski W.A.
• Języki publikacji: EN

Abstrakty

EN

Kynurenic acid (KYNA) is a broad spectrum antagonist of ionotropic glutamate receptors, preferentially active at the strychnine-insensitive glycine allosteric site of the N-methyl-D-aspartate (NMDA) receptor, and a noncompetitive antagonist of alpha7 nicotinic receptor. Animal studies showed that it possesses anticonvulsant and neuroprotective properties. Its involvement in the pathophysiology of various brain disorders was suggested. In this study, the effect of pesticides on KYNA production in brain cortical slices was investigated. Pyrethroids, deltamethrin and fenpropathrin significantly lowered KYNA production. Methomyl, bensultap, fipronil, diquat and MCPA were ineffective in this regard. In view of this data, the inhibition of KYNA synthesis appear to merit further investigation as a potential factor contributing to the toxicology of pyrethroids.

Słowa kluczowe

EN

pesticide; kynurenic acid; production; rat; brain slice; N-methyl-D-aspartate receptor

• Wydawca: -
• Czasopismo: Annals of Agricultural and Environmental Medicine
• Rocznik: 2005
• Tom: 12
• Numer: 2
• Opis fizyczny: p.177-179,ref.

Twórcy

autor

Zielinska E.

• Institute of Agricultural Medicine, Jaczewskiego 2, 20-090 Lublin, Poland

autor

Kocki T.

autor

Saran T.

autor

Borbely S.

autor

Kuc D.

autor

Vilagi I.

autor

Urbanska E.M.

autor

Turski W.A.

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