Comparative studies on O-acetylhomoserine sulfhydrylase: physiological role and characterization of the Aspergillus nidulans enzyme

• Autorzy: Brzywczy J. , Yamagata S. , Paszewski A.
• Języki publikacji: EN

Abstrakty

O-acetylhomoserine sulfhydrylase (OAH SHLase) from Aspergillus nidulans is an oligomeric protein with a broad substrate specificity with regard to sulfhydryl compounds. As its Saccharomyces cerevisiae counterpart the enzyme also reacts with O-acetylserine and is inhibited by carbonyl reagents but not by antiserum raised against the yeast enzyme. In contrast to Saccharomyces cerevisiae the enzyme is not essential for Aspergillus nidulans as indicated by the completely prototrophic phenotype of OAH SHLase-negative mutants. Its major physiological role in Aspergillus nidulans seems to be recycling of the thiomethyl group of methylthio- adenosine but it is also a constituent of the alternative pathway of cysteine synthesis.

Słowa kluczowe

EN

Aspergillus nidulans; O-acetylhomoserine; sulphydrylase; physiology; enzyme

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1993
• Tom: 40
• Numer: 3
• Opis fizyczny: p.421-428,fig.

Twórcy

autor

Brzywczy J.

• Polish Academy of Sciences, ul.Pawinskiego 5A, 020-106 Warszawa, Poland

autor

Yamagata S.

autor

Paszewski A.

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