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2000 | 44 | 2 |

Tytuł artykułu

Comparison of effects of vitamin C and selenium on renal and hepatic superoxide dismutase activities in cadmium intoxicated rats

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Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Male Wistar rats on a standard or vitamin C or selenium supplemented diet received orally a solution of cadmium chloride at a dose corresponding to 10 mg of cadmium/kg of diet. Rats were killed within 28 days of cadmium administration. Results showed that the cadmium intoxication decreased renal and hepatic superoxide dismutase (SOD) activity on day 7 and increased on days 14, 21 and 28. Rats fed the selenium or vitamin C supplemented diet exhibited time- and organ-dependent alterations in SOD activity. In several time-points results varied from those found in intact rats and those treated with cadmium.

Wydawca

-

Rocznik

Tom

44

Numer

2

Opis fizyczny

p.247-251

Twórcy

autor
  • National Veterinary Research Institute, 24-100 Pulawy, Poland
autor

Bibliografia

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  • 3. Chung A.S., Maines M.D.: Differential effect of cadmium on GSH-peroxidase activity in the Leyding and the Sertoli cells of rat testis. Suppresion by selenium and the possible relationship to heme concentration. Biochem. Pharmac., 1987, 36, 1367-1372.
  • 4. Elsenhans B., Schmolke G., Kolb K., Stokes J., Forth W.: Metal-metal interactions among dietary toxic and essential trace metals in the rat. Ecotox. Environ. Safety 1987, 14, 275-287.
  • 5. Figueiredo-Pereira M.E., Yakushin S., Cohen G.: Disruption of the intracellular sulfhydryl homeostasis by cadmium-induced oxidative stress leads to protein thiolation and ubiquitination in neuronal cells. J Biol. Chem. 1998, 273, 12703-12709.
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  • 7. Guillot I., Lohr B., Weiser H., Halbach S., Rambeck W.A.: Influence of vitamin C on cadmium and mercury accumulation. J. Anim. Phys. Anim. Nutr. 1998, 80, 167-169.
  • 8. Gupta S., Athar M., Behari J.R., Srivastava R.C.: Cadmium -mediated induction of cellular defence mechanism: a novel example for the development of adaptative response against a toxicant. Industrial Health, 1991, 29, 1-9.
  • 9. Holovska K., Lenartova V., Pedrajas J.R.: Superoxide dismutase, glutathione peroxidase and glutathione reductase in sheep organs. Comp. Biochem. Physiol. 1996, 115, 451-456.
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  • 12. Lowry O.H., Rosenbrough N.J., Farr A.L., Randall R.J.: Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193, 265-275.
  • 13. Marklund S., Marklund G.: lnvolvement of the superoxide anion radical in the autoxidation of pyrogallol and convenient assay for superoxide dismutase. Eur. J. Biochem. 1974, 47, 469-474.
  • 14. Meister A.: Glutathione ascorbate, and cellular protection. Canc. Res. (Suppl.) 1994, 54, 1969-1975.
  • 15. Novelli E.L.B., Vieira E.P., Rodrigues N.L., Ribas B.O.: Risk assesment of cadmium toxicity on hepatic and renal tissues of rats. Environ Res., Section A, 1998, 79, 102-105.
  • 16. Parke, D.V., Ioannides C.: The effects of nutrition on chemical toxicity. Drug Met. Rev. 1994, 26, 739-765.
  • 17. Potter S.D., Matrone G.: A tissue culture model for mercury-selenium interactions. Toxic. Appl Pharm. 1977, 40, 201-215.
  • 18. Rambeck W.A., Guillot I.: Zur Bioverfügbarkeit von Kadmium: Einflus von Vitamin C und Phytase beim Hühnerküken. Tierärztl. Prax. 1996, 24, 467-470.
  • 19. Singhal R.K., Anderson M.E., Meister A.: Glutathione, a first line of defence against cadmium toxicity. FASEB Journal 1987, 1, 220-223.
  • 20. Wahba Z.Z., Coogan T.P., Rhodes S.W., Waalkes M.P.: Protective effects of selenium on cadmium toxicity in rats: role of altered toxicokinetics and metallothionein. J. Toxicol. and Environ. Health. 1993, 38, 171-182.
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Typ dokumentu

Bibliografia

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