Chemical modification of lysine and arginine residues of bovine heart 2-oxoglutarate dehydrogenase: Effect on the enzyme activity and regulation

• Autorzy: Ostrovtsova S. A.
• Języki publikacji: EN

Abstrakty

EN

Chemical modification of arginine and lysine residues of bovine heart 2-oxoglutarate dehydrogenase with phenylglyoxal and pyridoxal 5'-phosphate inactivated the enzyme, indicating the importance of these residues for the catalysis. Inactivation caused by pyridoxal 5'-phosphate was prevented in the presence of thiamine pyrophosphate and Mg2+ allowing the assumption that lysine residues participate in binding of the cofactor.

Słowa kluczowe

EN

2-oxoglutarate dehydrogenase; chemical modification; regulation; bovine heart; enzyme activity; heart; arginine; lysine

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1998
• Tom: 45
• Numer: 4
• Opis fizyczny: p.1031-1036,fig.

Twórcy

autor

Ostrovtsova S. A.

• National Academy of Sciences of Belarus, BLK-50, 230009 Grodno, Belarus

Bibliografia

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