Photodynamic effect of lanthanide derivatives of meso-tetra[N-methyl-4-pyridyl]porphine against Staphylococcus aureus

• Autorzy: Jurczak A. , Szramka B. , Grinholc M. , Legendziewicz J. , Bielawski K.P.
• Języki publikacji: EN

Abstrakty

EN

Photodynamic therapy (PDT), used for cancer treatment, is also an alternative method for eradication of drug-resistant bacteria. This method utilizes a nontoxic light-activated dye, called a photosensitizer, and visible light to produce reactive oxygen species that lead to bacterial cell death. The purpose of this study was to investigate the bactericidal effect of PDT using lanthanide derivatives of meso-tetra(N-methyl-4-pyridyl)porphine against Staphylococcus aureusstrains. The new photosensitizers appeared to be photodynamically ineffective. No enhancement of antistaphylococcal activity of TMPyP was observed after the conjugation of the porphyrin with lanthanide ions. Additionally, a significant difference in the susceptibility of two bacterial strains to unmodified TMPyP was observed.

Słowa kluczowe

PL

Staphylococcus aureus; methicillin-resistant strain; photodynamic therapy; photosensitizer; porphyrin

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2008
• Tom: 55
• Numer: 3
• Opis fizyczny: p.581-585,fig.,ref.

Twórcy

autor

Jurczak A.

• University of Gdansk and Medical University of Gdansk, Kladki 24, 80-822 Gdansk, Poland

autor

Szramka B.

autor

Grinholc M.

autor

Legendziewicz J.

autor

Bielawski K.P.

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